ACE2 Polyclonal Antibody

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SKU:
AGEL2118
€194

Description

ACE2 Receptor - Background Information

The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.

ACE2 Polyclonal Antibody Properties

Information Description

Immunogen

Synthetic peptide of human ACE2

Source

Rabbit

Reactivity

Human,Mouse,Rat

Application

IHC,ELISA

Concentration

0.5 mg/mL

Recommended Dilution

IHC 1:100-1:300

Clone No.

N/A; Affinity purification

Isotype

IgG

Conjugation

Unconjugated

Storage

Store at -20℃. Avoid freeze / thaw cycles. PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Tissue Specificity

Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. Secreted and Cell membrane.

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