ADAMTS5 Antibody (PACO59549)
- SKU:
- PACO59549
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | ADAMTS5 Antibody (PACO59549) |
| Antibody SKU: | PACO59549 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 5 protein (535-646AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO59549 diluted at 1:400 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu- |-Ala-393' site, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2), ADAMTS5, ADAMTS11 ADMP2 |
| UniProt Protein Function: | ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Secreted; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 21q21.3 Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region Molecular Function:integrin binding; protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: protein amino acid O-linked glycosylation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; proteolysis; post-translational protein modification |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q9UNA0 |
| NCBI GenInfo Identifier: | 317373326 |
| NCBI Gene ID: | 11096 |
| NCBI Accession: | Q9UNA0.2 |
| UniProt Related Accession: | Q9UNA0 |
| Molecular Weight: | |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| NCBI Official Symbol: | ADAMTS5 |
| NCBI Official Synonym Symbols: | ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| UniProt Synonym Protein Names: | A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2 |
| UniProt Gene Name: | ADAMTS5 |
| UniProt Entry Name: | ATS5_HUMAN |
| Antibodies | ELISA Kits |
| Anti-ADAMTS5 Antibody (CAB2836) | Human ADAMTS5 ELISA Kit |
| Human A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
