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Anti-Phospho-I?Balpha-S32 Antibody (CABP1220)

SKU:
CABP1220
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
IKBA
MAD-3
NFKBI
IKB alpha
NFKBIA
EDAID2
Research Area:
Immunology
€329 - €419
Frequently bought together:

Description

Product Name:Phospho-I?B?-S32 Rabbit pAb
Product Code:CABP1220
Size:50uL, 100uL
Synonyms:IKBA, MAD-3, NFKBI, IKB alpha, NFKBIA, EDAID2
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S32 of human NFKBIA.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:1000
Reactivity:Human, Mouse
Positive Samples:HeLa, NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding S32 of human NFKBIA.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4792
Uniprot:P25963
Cellular Location:Cytoplasm, Nucleus
Calculated MW:35kDa
Observed MW:40kDa
UniProt Protein Function:Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
NCBI Summary:This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]
UniProt Code:P25963
NCBI GenInfo Identifier:126682
NCBI Gene ID:4792
NCBI Accession:P25963.1
UniProt Secondary Accession:P25963,B2R8L6,
UniProt Related Accession:P25963
Molecular Weight:35,609 Da
NCBI Full Name:NF-kappa-B inhibitor alpha
NCBI Synonym Full Names:NFKB inhibitor alpha
NCBI Official Symbol:NFKBIA  
NCBI Official Synonym Symbols:IKBA; MAD-3; NFKBI  
NCBI Protein Information:NF-kappa-B inhibitor alpha
UniProt Protein Name:NF-kappa-B inhibitor alpha
UniProt Synonym Protein Names:I-kappa-B-alpha; IkB-alpha; IkappaBalpha; Major histocompatibility complex enhancer-binding protein MAD3
Protein Family:NF-kappa-B inhibitor
UniProt Gene Name:NFKBIA  
UniProt Entry Name:IKBA_HUMAN

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