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Anti-Phospho-IRE1-Ser724/726 Antibody (CABP0959)

SKU:
CABP0959
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ERN1
IRE1
IRE1P
IRE1a
hIRE1p
Research Area:
Cell Death
€129 - €529
Frequently bought together:

Description

Product Name:Phospho-IRE1-Ser724/726 Rabbit pAb
Product Code:CABP0959
Size:20uL, 50uL, 100uL
Synonyms:ERN1, IRE1, IRE1P, IRE1a, hIRE1p
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around of human Phospho-IRE1-Ser724/726.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around of human Phospho-IRE1-Ser724/726.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2081
Uniprot:O75460
Cellular Location:Endoplasmic reticulum membrane, Single-pass type I membrane protein
Calculated MW:6kDa/109kDa
Observed MW:Refer to figures
NCBI Summary:This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
UniProt Code:O75460
NCBI GenInfo Identifier:193806335
NCBI Gene ID:2081
NCBI Accession:O75460.2
UniProt Secondary Accession:O75460,Q76MJ5,
UniProt Related Accession:O75460
Molecular Weight:Observed: 110 kDaPredicted: 110 kDa
NCBI Full Name:Serine/threonine-protein kinase/endoribonuclease IRE1
NCBI Synonym Full Names:endoplasmic reticulum to nucleus signaling 1
NCBI Official Symbol:ERN1  
NCBI Official Synonym Symbols:IRE1; IRE1P; IRE1a; hIRE1p  
NCBI Protein Information:serine/threonine-protein kinase/endoribonuclease IRE1
UniProt Protein Name:Serine/threonine-protein kinase/endoribonuclease IRE1
UniProt Synonym Protein Names:Endoplasmic reticulum-to-nucleus signaling 1; Inositol-requiring protein 1; hIRE1p; Ire1-alpha; IRE1a
Protein Family:Serine/threonine-protein kinase/endoribonuclease
UniProt Gene Name:ERN1  
UniProt Entry Name:ERN1_HUMAN

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