null

Anti-Phospho-NRAS-S89 Antibody (CABP1169)

SKU:
CABP1169
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
NRAS
ALPS4
CMNS
N-ras
NCMS
NRAS1
NS6
GTPase NRas
Research Area:
Cell Biology
$167 - $587
Frequently bought together:

Description

Product Name:Phospho-NRAS-S89 Rabbit pAb
Product Code:CABP1169
Size:20uL, 50uL, 100uL
Synonyms:NRAS, ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, GTPase NRas
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding S89 of human NPhospho-NRAS-S89.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A phospho specific peptide corresponding to residues surrounding S89 of human NPhospho-NRAS-S89.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4893
Uniprot:P01111
Cellular Location:Cell membrane, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor
Calculated MW:21kDa
Observed MW:Refer to Figures
UniProt Protein Function:NRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Oncoprotein; G protein, monomeric; G protein; G protein, monomeric, Ras

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: Golgi apparatus; membrane; plasma membrane

Molecular Function:protein complex binding

Biological Process: axon guidance; epidermal growth factor receptor signaling pathway; leukocyte migration; MAPKKK cascade; Ras protein signal transduction; stimulatory C-type lectin receptor signaling pathway

Disease: Colorectal Cancer; Melanocytic Nevus Syndrome, Congenital; Melanosis, Neurocutaneous; Nevus, Epidermal; Noonan Syndrome 6; Ras-associated Autoimmune Leukoproliferative Disorder; Schimmelpenning-feuerstein-mims Syndrome; Thyroid Carcinoma, Follicular

NCBI Summary:This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
UniProt Code:P01111
NCBI GenInfo Identifier:131883
NCBI Gene ID:4893
NCBI Accession:P01111.1
UniProt Secondary Accession:P01111,Q14971, Q15104, Q15282,
UniProt Related Accession:P01111
Molecular Weight:21,229 Da
NCBI Full Name:GTPase NRas
NCBI Synonym Full Names:neuroblastoma RAS viral oncogene homolog
NCBI Official Symbol:NRAS  
NCBI Official Synonym Symbols:NS6; CMNS; NCMS; ALPS4; N-ras; NRAS1  
NCBI Protein Information:GTPase NRas
UniProt Protein Name:GTPase NRas
UniProt Synonym Protein Names:Transforming protein N-Ras
Protein Family:GTPase
UniProt Gene Name:NRAS  
UniProt Entry Name:RASN_HUMAN

Related Products