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Biosimilar Drug Target Proteins

Recombinant proteins are an excellent tool in modelling drug effectiveness, drug development and in pharmacokinetics (PK) assays. Assay genie provides a range of bioactive recombinant proteins that have undergone strict quality control, purity testing and thermal stability tests. These recombinant proteins are known targets of major biologic drugs used in development of CAR-T-cell therapies, immune checkpoint therapies and solid tumour research.

Features & Benefits

  • Recombinant proteins expressed in mammalian HEK293 cells with authentic posttranslational modifications
  • Cultured In serum free medium to minimise host cell contamination
  • EDM-Fc provides greater stability and solubility
  • Different tags available on selected proteins
  • Extensive testing for quality and function

Applications

  • Used as native immunogens in the development of therapeutic antibodies
  • In vitro testing of therapeutic drugs
  • In vitro testing of protein functions
  • Development of enzymatic assays
  • Positive controls in western blots and as standards in ELISA

Haematological Cancer Target Proteins

Product Name
Human BCMA Protein, hFc-His Tag Human CD38 Protein, hFc Tag
Human BCMA Protein, mFc Tag Human CD38 Protein, hFc-His Tag
Human CD114 Protein, His Tag Human CD5 Protein, His Tag
Human CD123 Protein, hFc-His Tag Human CD7 Protein, mFc Tag
Human CD138 Protein, hFc-His Tag Human CS1 Protein, hFc-His Tag
Human CD200 Protein, His Tag Human FCGR3A Protein (F176V), His Tag
Human CD22 Protein, hFc-His Tag Human FLT3 Ligand Protein, mFc-His Tag
Human CD30 Ligand Protein, mFc-His Tag Human FLT3 Protein, hFc-His Tag
Human CD30 Protein, His tag Human GPRC5D Protein, hFc-His Tag
Human CD33 Protein, hFc-His Tag Human ICAM-1 Protein, mFc Tag
Human CD34 Protein, His Tag Human NTB-A Protein, mFc-His Tag
Human CD37 Protein, hFc Tag Human ROR1 Protein, His Tag

Immune Checkpoint Target Proteins

Product Name
Human 2B4 Protein, hFc tag Human GITR Ligand Protein, His tag
Human 2B4 Protein, mFc-His Tag Human GITR Ligand Protein, mFc-His tag
Human 4-1BB Ligand Protein, mFc-His Tag Human GITR Protein, hFc-His tag
Human 4-1BB Protein, His tag Human GITR Protein, mFc-His tag
Human 4-1BB Protein, mFc-His Tag Human ICOS Protein, hFc tag
Human ACE2 Protein, hFc Tag Human ICOS Protein, mFc-His tag
Human ACE2 Protein, His Tag Human IL2RA Protein, His Tag
Human ACE2 Protein, mFc Tag Human IL2RB Protein, His Tag
Human B7-1 Protein, hFc Tag Human IL5 Protein, hFc Tag
Human B7-1 Protein, mFc-His Tag Human IL5 Protein, His Tag
Human B7-2 Protein, hFc Tag Human IL5RA Protein, hFc Tag
Human B7-2 Protein, mFc-His Tag Human IL5RA Protein, His Tag
Human B7-H2 Protein, mFc-His Tag Human IL6 Protein, mFc-His Tag
Human B7-H3 Protein, mFc-His Tag Human IL6R Protein, hFc Tag
Human BAFF Protein, hFc Tag Human IL6R Protein, His Tag
Human BAFF-R Protein, hFc Tag Human NKp30 Protein, hFc Tag
Human BAFF-R Protein, mFc Tag Human OX40 Protein, hFc-His tag
Human BTLA Protein, hFc Tag Human OX40L Protein, mFc-His tag
Human BTLA Protein, His Tag Human PD-1 Protein, His tag
Human BTLA Protein, mFc-His Tag Human PD-1 Protein, hFc-His tag
Human BTN3A1 Protein, mFc-His Tag Human PD-1 Protein, mFc-His tag
Human CD155 Protein, hFc tag Human PD-L1 Protein, His tag
Human CD155 Protein, mFc-His tag Human PD-L1 Protein, mFc-His tag
Human CD162 Protein, His Tag Human PDL2 Protein, His Tag
Human CD27 Protein, hFc Tag Human SELP Protein, hFc Tag
Human CD27 Protein, mFc-His Tag Human SIGLEC10 Protein, His Tag
Human CD28 Protein, mFc-His Tag Human SIRPα Protein, hFc-His Tag
Human CD40 Ligand Protein, hFc Tag Human SIRPα Protein, mFc Tag
Human CD40 Protein, mFc-His Tag Human SLAMF1 Protein, mFc-His tag
Human CD47 Protein, mFc-His Tag Human SLAMF5 Protein, mFc-His Tag
Human CD48 Protein, hFc Tag Human TIGIT Protein, hFc Tag
Human CD48 Protein, mFc-His Tag Human TIGIT Protein, His Tag
Human CD70 Protein, hFc-His Tag Human TIGIT Protein, mFc Tag
Human CD70 Protein, mFc-His Tag Human TIM3 Protein, mFc-His Tag
Human CD96 Protein, mFc-His tag Human TweakR Protein, mFc Tag
Human CTLA-4 Protein, hFc tag Mouse BTLA Protein, His Tag
Human CTLA-4 Protein, mFc-His Tag Mouse BTLA Protein, mFc Tag
Human DNAM-1 Protein, mFc-His Tag

Solid Tumour Target Proteins

Product Name
Human AXL Protein, mFc Tag Human MSLN(296-580) Protein, mFc-His Tag
Human AXL Protein, hFc Tag Human NKG2D Protein, mFc Tag
Human AXL Protein, His Tag Human PSCA Protein, hFc Tag
Human CEACAM5 Protein, His Tag Human ROR2 Protein, His Tag
Human CLDN6 Protein, mFc Tag Human TNFRSF10B Protein, mFc Tag
Human CSF1R Protein, His Tag Human TNFSF11 Protein, hFc Tag
Human EPCAM Protein, His Tag Human TNFSF12 Protein, hFc Tag
Human EPHA3 Protein, mFc-His Tag Human TNFα Protein, His Tag
Human FAP Protein, His Tag Human Trop2 Protein, mFc-His Tag
Human HER3 Protein, His Tag Mouse FAP Protein, C-mFc Tag
Human IL17RA Protein, His Tag Mouse FAP Protein, N-mFc Tag

Pipeline Cancer and Immune Target Proteins

Product Name
Human 5T4 Protein, His Tag Human DCK Protein, hFc Tag Human MAGE-A6 Protein, hFc Tag
Human ABCB5 Protein, hFc Tag Human DKK1 Protein, hFc Tag Human MAGE-C2 Protein, hFc Tag
Human ACPP Protein, hFc Tag Human DKK1 Protein, hFc Tag Human MAP2K1 Protein, hFc Tag
Human ADABP Protein, hFc Tag Human DKK2 Protein, hFc Tag Human MAP2K2 Protein, hFc Tag
Human ADAM17 Protein, hFc Tag Human DLK1 Protein, hFc Tag Human MAPK14 Protein, hFc Tag
Human ADAM9 Protein, hFc Tag Human DLX3 Protein, hFc Tag Human MASP2 Protein, hFc Tag
Human ADORA2A Protein, hFc Tag Human EEF1A2 Protein, hFc Tag Human MERTK Protein, hFc Tag
Human ADORA2B Protein, hFc Tag Human EGF Protein, hFc Tag Human MICA Protein, His Tag
Human ADORA3 Protein, hFc Tag Human EGFR Protein, His Tag Human MICB Protein, His Tag
Human AFP Protein, hFc Tag Human EGFR5 Protein, hFc Tag Human MIF Protein, hFc Tag
Human AIM2 Protein, hFc Tag Human EIF2AK3 Protein, hFc Tag Human MLANA Protein, hFc Tag
Human ALK Protein, hFc Tag Human EMR1 Protein, hFc Tag Human MMP11 Protein, hFc Tag
Human AMHR2 Protein, hFc Tag Human ENPP3 Protein, hFc Tag Human MOSPD2 Protein, hFc Tag
Human ANG1 Protein, hFc Tag Human EPHA2 Protein, His Tag Human MR1 Protein, hFc Tag
Human ANGPT2 Protein, hFc Tag Human EPS8 Protein, hFc Tag Human MRP1 Protein, hFc Tag
Human ANGPTL3 Protein, His Tag Human ERG Protein, hFc Tag Human MST1R Protein, hFc Tag
Human ANPEP Protein, hFc Tag Human EZH2 Protein, hFc Tag Human mTOR Protein, hFc Tag
Human ARG1 Protein, hFc Tag Human FASLG Protein, hFc Tag Human MUC1 Protein, hFc Tag
Human ASNS Protein, hFc Tag Human FCMR Protein, hFc Tag Human MUC1 Protein, His Tag
Human ASPH Protein, hFc Tag Human FGF2 Protein, hFc Tag Human MVP Protein, hFc Tag
Human ATM Protein, hFc Tag Human FGL1 Protein, hFc Tag Human MYB Protein, hFc Tag
Human ATR Protein, hFc Tag Human FLT1 Protein, hFc Tag Human MYBL2 Protein, hFc Tag
Human B7-1 Protein, hFc Tag Human FMNL1 Protein, hFc Tag Human Myeloblastin Protein, hFc Tag
Human B7-1 Protein, mFc-His Tag Human FN1 Protein, hFc Tag Human NCR1 Protein, hFc Tag
Human B7-2 Protein, hFc Tag Human FOLR1 Protein, His Tag Human NECTIN4 Protein, hFc Tag
Human B7-H4 Protein, hFc Tag Human FOLR2 Protein, hFc Tag Human NFAT Protein, hFc Tag
Human B7-H6 Protein, His Tag Human FOXM1 Protein, hFc Tag Human NLRP3 Protein, hFc Tag
Human BAI1 Protein, hFc Tag Human FSHR Protein, hFc Tag Human N-Myc Protein, hFc Tag
Human BARD1 Protein, hFc Tag Human FUT3 Protein, hFc Tag Human NR2F6 Protein, hFc Tag
Human BCL2 Protein, hFc Tag Human Galectin 9 Protein, hFc Tag Human NR3C1 Protein, hFc Tag
Human BCMA Protein, His Tag Human Gastrin Protein, hFc Tag Human NR3C4 Protein, hFc Tag
Human BRD4 Protein, hFc Tag Human GDNF Protein, hFc Tag Human NR4A1 Protein, hFc Tag
Human BTK Protein, hFc Tag Human GNRHR Protein, hFc Tag Human NRG1 Protein, hFc Tag
Human C5AR1 Protein, hFc Tag Human GP73 Protein, hFc Tag Human NRG1 Protein, hFc Tag
Human CA9 Protein, His Tag Human gp96 Protein, hFc Tag Human NS1 Protein, hFc Tag
Human CAK1 Protein, hFc Tag Human GPA33 Protein, hFc Tag Human NY-ESO-1 Protein, hFc Tag
Human CALCA Protein, hFc Tag Human GPC1 Protein, hFc Tag Human P2RX7 Protein, hFc Tag
Human CALR Protein, hFc Tag Human GPC2 Protein, hFc Tag Human P38 Protein, hFc Tag
Human CB1 Protein, hFc Tag Human GUCY2C Protein, hFc Tag Human P53 Protein, hFc Tag
Human CB1 Protein, hFc Tag Human HAGE Protein, hFc Tag Human PARP1 Protein, hFc Tag
Human CB2 Protein, hFc Tag Human HBL Protein, hFc Tag Human PBF Protein, hFc Tag
Human CBLB Protein, hFc Tag Human HDAC6 Protein, hFc Tag Human PCDH18 Protein, hFc Tag
Human CCL2 Protein, hFc Tag Human Her2 Protein, His Tag Human PIK3CA Protein, hFc Tag
Human CCL20 Protein, hFc Tag Human HGF Protein, hFc Tag Human PMEL Protein, hFc Tag
Human CCR1 Protein, hFc Tag Human HLA-A Protein, hFc Tag Human POTGlu Protein, hFc Tag
Human CCR2 Protein, hFc Tag Human HPSE Protein, hFc Tag Human PPT Protein, hFc Tag
Human CCR3 Protein, hFc Tag Human HSP105 Protein, His Tag Human PRAME Protein, hFc Tag
Human CCR4 Protein, hFc Tag Human HVEM Protein, His Tag Human PRDX2 Protein, hFc Tag
Human CCR5 Protein, hFc Tag Human IDH1 Protein, hFc Tag Human PROM1 Protein, hFc Tag
Human CCR7 Protein, hFc Tag Human IDO1 Protein, hFc Tag Human PROM1 Protein, hFc Tag
Human CCR8 Protein, hFc Tag Human IFNAR1 Protein, hFc Tag Human PSMA Protein, hFc Tag
Human CCR9 Protein, hFc Tag Human IFNAR2 Protein, hFc Tag Human PSMA Protein, His Tag
Human CD10 Protein, hFc Tag Human IFNB Protein, hFc Tag Human PSMA Protein, mFc Tag
Human CD11 Protein, hFc Tag Human IFNG Protein, hFc Tag Human PTGER2 Protein, hFc Tag
Human CD117 Protein, His Tag Human IFNGR1 Protein, hFc Tag Human PTGER4 Protein, hFc Tag
Human CD130 Protein, hFc Tag Human IFNGR2 Protein, hFc Tag Human PTK7 Protein, hFc Tag
Human CD147 Protein, hFc Tag Human IGF-1R Protein, hFc Tag Human PVRIG Protein, hFc Tag
Human CD160 Protein, hFc Tag Human IGFBP2 Protein, hFc Tag Human RET Protein, hFc Tag
Human CD160 Protein, His Tag Human IgG1-Fc Protein Human RhoC Protein, hFc Tag
Human CD171 Protein, His Tag Human IL10 Protein, hFc Tag Human RIG-I Protein, hFc Tag
Human CD19 Protein, hFc-His tag Human IL10R Protein, hFc Tag Human ROBO1 Protein, hFc Tag
Human CD1A Protein, hFc Tag Human IL12RB1 Protein, hFc Tag Human RORC Protein, hFc Tag
Human CD1D Protein, hFc Tag Human IL13 Protein, hFc Tag Human SCGB2A2 Protein, hFc Tag
Human CD20 Protein, hFc Tag Human IL13RA1 Protein, His Tag Human SFRP2 Protein, His Tag
Human CD200R1 Protein, hFc Tag Human IL15 Protein, hFc Tag Human SIGLEC15 Protein, mFc-His Tag
Human CD21 Protein, hFc Tag Human IL15RA Protein, hFc Tag Human SIGLEC9 Protein, hFc Tag
Human CD24 Protein, hFc Tag Human IL15RA Protein, hFc Tag Human SIM-2 Protein, hFc Tag
Human CD24 Protein, hFc Tag Human IL17A Protein, hFc Tag Human SLAMF3 Protein, hFc Tag
Human CD3 delta Protein, hFc Tag Human IL17B Protein, hFc Tag Human SLAMF3 Protein, His Tag
Human CD305 Protein, hFc Tag Human IL17RB Protein, hFc Tag Human SLAMF5 Protein, mFc-His Tag
Human CD32 Protein, hFc Tag Human IL18 Protein, hFc Tag Human SOAT1 Protein, hFc Tag
Human CD36 Protein, hFc Tag Human IL18R1 Protein, hFc Tag Human SPAM1 Protein, hFc Tag
Human CD39 Protein, hFc Tag Human IL1A Protein, hFc Tag Human SSTR2 Protein, hFc Tag
Human CD3E Protein, hFc Tag Human IL1B Protein, hFc Tag Human STAT1 Protein, hFc Tag
Human CD4 Protein, hFc Tag Human IL1R1 Protein, hFc Tag Human STAT3 Protein, hFc Tag
Human CD43 Protein, hFc Tag Human IL1R3 Protein, hFc Tag Human STAT5 Protein, hFc Tag
Human CD44 Protein, His Tag Human IL2 Protein, hFc Tag Human STEAP1 Protein, hFc Tag
Human CD46 Protein, His Tag Human IL20 Protein, hFc Tag Human TACI Protein, hFc Tag
Human CD52 Protein, mFc Tag Human IL21 Protein, hFc Tag Human TERT Protein, hFc Tag
Human CD56 Protein, hFc Tag Human IL21R Protein, hFc Tag Human TFDP3 Protein, hFc Tag
Human CD56 Protein, His Tag Human IL27RA Protein, hFc Tag Human TGFA Protein, hFc Tag
Human CD6 Protein, hFc Tag Human IL2RG Protein, hFc Tag Human TGFB1 Protein, hFc Tag
Human CD70 Protein, mFc-His Tag Human IL4RA Protein, hFc Tag Human TGFB2 Protein, hFc Tag
Human CD73 Protein, hFc Tag Human IL-7RA Protein, hFc Tag Human TGFB3 Protein, hFc Tag
Human CD79B Protein, hFc Tag Human IL-8 Protein, hFc Tag Human TGFBR1 Protein, hFc Tag
Human CD8A Protein, hFc Tag Human IL9R Protein, hFc Tag Human TGFBR2 Protein, hFc Tag
Human CD9 Protein, hFc Tag Human ILDR2 Protein, hFc Tag Human TIE2 Protein, hFc Tag
Human CD99 Protein, hFc Tag Human IRAK1 Protein, hFc Tag Human TK1 Protein, hFc Tag
Human CDH17 Protein, hFc Tag Human IRAK3 Protein, hFc Tag Human TLR1 Protein, hFc Tag
Human CDH3 Protein, hFc Tag Human IRAK4 Protein, hFc Tag Human TLR2 Protein, hFc Tag
Human CEACAM-1 Protein, hFc Tag Human ITGA1 Protein, hFc Tag Human TLR3 Protein, hFc Tag
Human CEACAM6 Protein, hFc Tag Human ITGA4 Protein, hFc Tag Human TLR4 Protein, hFc Tag
Human CEACAM8 Protein, hFc Tag Human ITGAM Protein, hFc Tag Human TLR5 Protein, hFc Tag
Human CHEK2 Protein, hFc Tag Human ITGAV Protein, hFc Tag Human TLR7 Protein, hFc Tag
Human CLDN3 Protein, hFc Tag Human ITGB1 Protein, hFc Tag Human TLR8 Protein, hFc Tag
Human CLEC12A Protein, His Tag Human ITGB5 Protein, hFc Tag Human TLR9 Protein, hFc Tag
Human CLEC2D Protein, hFc Tag Human ITGB7 Protein, hFc Tag Human TM4SF1 Protein, hFc Tag
Human COLEC10 Protein, hFc Tag Human KIF20A Protein, hFc Tag Human TM4SF1 Protein, hFc Tag
Human COX Protein, hFc Tag Human KIR2DL1 Protein, hFc Tag Human TM4SF1 Protein, hFc Tag
Human COX1 Protein, hFc Tag Human KIR2DL2 Protein, hFc Tag Human TMEM173 Protein, hFc Tag
Human COX2 Protein, hFc Tag Human KIR2DL3 Protein, hFc Tag Human TNFRSF11A Protein, hFc Tag
Human CRBN Protein, hFc Tag Human KLK3 Protein, hFc Tag Human TNFRSF1A Protein, hFc Tag
Human CRLF2 Protein, hFc Tag Human KLRC1 Protein, hFc Tag Human TNFSF13 Protein, hFc Tag
Human CSF Protein, hFc Tag Human KLRG1 Protein, hFc Tag Human TPH1 Protein, hFc Tag
Human CSF1 Protein, hFc Tag Human KLRG1 Protein, hFc Tag Human TRAIP Protein, hFc Tag
Human CSF2RA Protein, hFc Tag Human KRAS Protein, hFc Tag Human TRP2 Protein, hFc Tag
Human CSPG4 Protein, His Tag Human LAG3 Protein, hFc Tag Human TSHR Protein, hFc Tag
Human CT83 Protein, hFc Tag Human LAG3 Protein, His Tag Human TYR Protein, hFc Tag
Human CTCFL Protein, hFc Tag Human LALBA Protein, hFc Tag Human TYRO3 Protein, hFc Tag
Human CTNNB1 Protein, hFc Tag Human LAMP Protein, hFc Tag Human ULBP2 Protein, hFc Tag
Human CX3CR1 Protein, hFc Tag Human LGALS3 Protein, hFc Tag Human UTA2-1 Protein, hFc Tag
Human CXCL1 Protein, hFc Tag Human LGALS3BP Protein, hFc Tag Human VEGF Protein, hFc Tag
Human CXCL12 Protein, hFc Tag Human LIGHT Protein, hFc Tag Human VEGFA Protein, His Tag
Human CXCL13 Protein, hFc Tag Human LILRA5 Protein, hFc Tag Human VEGFR2 Protein, His Tag
Human CXCL16 Protein, hFc Tag Human LMP2 Protein, hFc Tag Human VGLL4 Protein, hFc Tag
Human CXCL9 Protein, hFc Tag Human LRRC32 Protein, hFc Tag Human VSIG4 Protein, hFc Tag
Human CXCR1 Protein, hFc Tag Human LXRA Protein, hFc Tag Human VSIR Protein, hFc Tag
Human CXCR2 Protein, hFc Tag Human LXRB Protein, hFc Tag Human XAGE1A Protein, hFc Tag
Human CXC-R3 Protein, hFc Tag Human MAGEA1 Protein, hFc Tag Human XIAP Protein, hFc Tag
Human CXC-R4 Protein, hFc Tag Human MAGE-A10 Protein, hFc Tag Human YAP1 Protein, His Tag
Human CXC-R5 Protein, hFc Tag Human MAGE-A3 Protein, hFc Tag Human ZP3 Protein, hFc Tag
Human CXCR7 Protein, hFc Tag Human MAGE-A4 Protein, hFc Tag

Technology

Most therapeutic antibodies target the extracellular domains of membrane proteins or secreted proteins. Expressing and purifying membrane proteins in their full length and native confirmation is particularly challenging. Assay Genie provides extra-cellular domain (ECD)-Fc fusion proteins utilising HEK293 mammalian expression systems to ensure authentic posttranslational modification and a higher chance of producing proteins with good solubility and correct folding.

Quality Control Data

Figure 1: ELISA plate precoated with 2 µg/ml Human CD138 hDc-His tagged protein. Can be detected with Anti-CD138 antibody in a range of 1.6-200 ng/ml.

Figure 2: Human CD138, hFc-His Tag on SDS-PAGE under reducing condition.

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