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Spindle assembly checkpoint The spindle assembly checkpoint (SAC), or mitotic checkpoint, is the main cell cycle control mechanism that governs mitosis. Incorrect spindle attachment causes the spindle assembly checkpoint to generate a wait anaphase signal that prevents the activation of the anaphase promoting complex (APC), an ubiquitin E3 ligase essential for progression of the cell cycle. Conserved components of the mammalian SAC include B …