Anti-CD93 Antibody (PACO18980)

Antibody Name:	CD93 Antibody (PACO18980)
Antibody SKU:	PACO18980
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:3000-1:10000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human CD93

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18980(CD93 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18980(CD93 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.

Synonyms:

CD93 molecule

UniProt Protein Function:	CD93: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
UniProt Protein Details:	Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: cell surface; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane Molecular Function:protein binding; complement component C1q binding; receptor activity; calcium ion binding; carbohydrate binding Biological Process: macrophage activation; cell-cell adhesion; viral reproduction; phagocytosis
NCBI Summary:	The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9NPY3
NCBI GenInfo Identifier:	21759074
NCBI Gene ID:	22918
NCBI Accession:	Q9NPY3.3
UniProt Secondary Accession:	Q9NPY3,O00274,
UniProt Related Accession:	Q9NPY3
Molecular Weight:	68,560 Da
NCBI Full Name:	Complement component C1q receptor
NCBI Synonym Full Names:	CD93 molecule
NCBI Official Symbol:	CD93
NCBI Official Synonym Symbols:	C1QR1; C1qRP; CDw93; ECSM3; MXRA4; C1qR(P); dJ737E23.1
NCBI Protein Information:	complement component C1q receptor; C1qR; CD93 antigen; C1q receptor 1; C1q/MBL/SPA receptor; matrix-remodelling associated 4; matrix-remodeling-associated protein 4; complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1
UniProt Protein Name:	Complement component C1q receptor
UniProt Synonym Protein Names:	C1q/MBL/SPA receptor; C1qR; C1qR(p); C1qRp; CDw93; Complement component 1 q subcomponent receptor 1; Matrix-remodeling-associated protein 4; CD_antigen: CD93
Protein Family:	Complement component C1q receptor
UniProt Gene Name:	CD93
UniProt Entry Name:	C1QR1_HUMAN

Antibodies	ELISA Kits
CD93 Antibody (PACO06893)	Human C1q R1 / CD93 ELISA Kit
	Human C1qR1 (Complement Component 1q Receptor) ELISA Kit (HUES01943)
	Human Complement component C1q receptor (CD93) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)