| UniProt Protein Function: | CDK12: a Ser/Thr protein kinase of the CMGC group and CDK family. Phosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Interacts with CCNL1 and CCNL2. Colocalized with nuclear speckles throughout interphase. Has a highly phosphorylated arginine/serine-rich (RS) domain N-terminal to the kinase domain. Chromosomal aberrations involving CDK12 may be a cause gastric cancer. Deletions within 17q12 region producing fusion transcripts with ERBB2, leading to CDK12-ERBB2 fusion leading to trunctated CDK12 protein not in-frame with ERBB2. Three isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA splicing; Protein kinase, CMGC; Motility/polarity/chemotaxis; Kinase, protein; Spliceosome; EC 2.7.11.23; Cell cycle regulation; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CRK7 subfamily; CDK/CRK7 subfamily Chromosomal Location of Human Ortholog: 17q12 Cellular Component: nucleoplasm; nuclear cyclin-dependent protein kinase holoenzyme complex; nucleolus; nuclear speck; nucleus Molecular Function:RNA polymerase subunit kinase activity; protein binding; cyclin binding; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity Biological Process: regulation of cell cycle; protein amino acid autophosphorylation; regulation of MAP kinase activity; RNA splicing; mRNA processing |
| UniProt Code: | Q9NYV4 |
| NCBI GenInfo Identifier: | 308153421 |
| NCBI Gene ID: | 51755 |
| NCBI Accession: | Q9NYV4.2 |
| UniProt Secondary Accession: | Q9NYV4,O94978, A7E2B2, B4DYX4, B9EIQ6, |
| UniProt Related Accession: | Q9NYV4 |
| Molecular Weight: | 141,449 Da |
| NCBI Full Name: | Cyclin-dependent kinase 12 |
| NCBI Synonym Full Names: | cyclin-dependent kinase 12 |
| NCBI Official Symbol: | CDK12 |
| NCBI Official Synonym Symbols: | CRK7; CRKR; CRKRS |
| NCBI Protein Information: | cyclin-dependent kinase 12; CDC2-related protein kinase 7; cell division protein kinase 12; Cdc2-related kinase, arginine/serine-rich; cell division cycle 2-related protein kinase 7 |
| UniProt Protein Name: | Cyclin-dependent kinase 12 |
| UniProt Synonym Protein Names: | Cdc2-related kinase, arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12 |
| UniProt Gene Name: | CDK12 |
| UniProt Entry Name: | CDK12_HUMAN |
