Chicken IFN gamma (Yeast-derived Recombinant Protein)
Interferon-gamma (IFN-gamma) is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-gamma belongs. IFN-gamma, or type II interferon, is a cytokine that is critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFN-gamma expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFN-gamma in the immune system stems in part from its ability to inhibit viral replication directly, but, most important, derives from its immunostimulatory and immunomodulatory effects. IFN-gamma is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops.
Recombinant Chicken IFN gamma Catalog Number CHKF0001 contains a single amino acid substitution compared to NCBI reference sequence NP_990480.1 (Thr at position 93 in place of Ile). This amino acid substitution was corrected to match the published sequence. The corrected recombinant protein is available (Catalog Number CHFI0001-5/CHFI0001-25/CHFI0001-100/CHFI0001-500) (Ile present at position 93).
IFNγ Homology Across Species
Meleagris gallopavo (turkey) IFNγ – 98%
Lagopus lagopus scotica(red grouse) IFNγ – 96%
Name: Chicken IFN gamma
Product Code: CHFI0001
Protein sizes: 5μg, 25μg, 100μg, 500μg
Source: The Chicken IFN gamma recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW: The Chicken IFN gamma recombinant protein has a predicted molecular weight of 16.7 kDa.
Protein Sequence: HTASSLNLVQ LQDDIDKLKA DFNSSHSDVA DGGPIIVEKL KNWTERNEKR IILSQIVSMY LEMLENTDKS KPHTKHISEE LYTLKNNLPD GVKKVKDIMD LAKLPMNDLR IQRKAANELF SILQKLVDPP SFKRKRSQSQ RRCNC (145)
Applications: The Chicken IFN gamma endotoxin-free recombinant protein can be used in cell culture, as an IFN gamma ELISA Standard, and as a Western Blot Control.