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CYR61 Antibody (PACO64575)

SKU:
PACO64575
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
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Description

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Antibody Name:CYR61 Antibody (PACO64575)
Antibody SKU:PACO64575
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000, ELISA:1:10000
Species Reactivity:Human,Mouse,Rat
Immunogen:CYR61 Polyclonal Antibody detects endogenous levels of protein.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:3CH61 antibody; CCN 1 antibody; CCN family member 1 antibody; CCN1 antibody; CYR 61 antibody; Cyr61 antibody; CYR61 protein antibody; CYR61_HUMAN antibody; Cysteine rich angiogenic inducer 61 antibody; Cysteine rich heparin binding protein 61 antibody; Cysteine-rich angiogenic inducer 61 antibody; GIG 1 antibody; GIG1 antibody; IBP-10 antibody; IGF-binding protein 10 antibody; Igfbp 10 antibody; IGFBP-10 antibody; Igfbp10 antibody; Insulin like growth factor binding protein 10 antibody; Insulin-like growth factor-binding protein 10 antibody; Protein CYR61 antibody; Protein GIG1 antibody
UniProt Protein Function:CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function:heparin binding; integrin binding; insulin-like growth factor binding; extracellular matrix binding

Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; cell proliferation; positive regulation of osteoblast differentiation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; positive regulation of cell migration; negative regulation of apoptosis

NCBI Summary:The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
UniProt Code:O00622
NCBI GenInfo Identifier:3023601
NCBI Gene ID:3491
NCBI Accession:O00622.1
UniProt Secondary Accession:O00622,O14934, O43775, Q9BZL7,
UniProt Related Accession:O00622
Molecular Weight:
NCBI Full Name:Protein CYR61
NCBI Synonym Full Names:cysteine-rich, angiogenic inducer, 61
NCBI Official Symbol:CYR61  
NCBI Official Synonym Symbols:CCN1; GIG1; IGFBP10  
NCBI Protein Information:protein CYR61; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10
UniProt Protein Name:Protein CYR61
UniProt Synonym Protein Names:CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1
Protein Family:Protein
UniProt Gene Name:CYR61  
UniProt Entry Name:CYR61_HUMAN

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