DOK7 Antibody (PACO23751)
- SKU:
- PACO23751
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | DOK7 Antibody (PACO23751) |
| Antibody SKU: | PACO23751 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from N-terminal of human DOK7. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from mouse brain cells, using DOK7 antibody. |
 | Immunofluorescence analysis of HepG2 cells, using DOK7 antibody. |
 | Immunohistochemistry analysis of paraffin-embedded human brain tissue using DOK7 antibody. |
| Background: | Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. |
| Synonyms: | Dok-7; downstream of tyrosine kinase 7; |
| UniProt Protein Function: | DOK7: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. Interacts with the cytoplasmic part of MUSK. Defects in DOK7 are the cause of congenital myasthenic syndrome type 1B or CMS1B. Three isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Activator Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: cell junction; plasma membrane; synapse Molecular Function:insulin receptor binding; lipid binding; protein kinase binding Disease: Fetal Akinesia Deformation Sequence; Myasthenia, Limb-girdle, Familial |
| NCBI Summary: | The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] |
| UniProt Code: | Q18PE1 |
| NCBI GenInfo Identifier: | 115311705 |
| NCBI Gene ID: | 285489 |
| NCBI Accession: | Q18PE1.1 |
| UniProt Secondary Accession: | Q18PE1,Q6P6A6, Q86XG5, Q8N2J3, Q8NBC1, A2A499, A2RRD4 E9PB56, |
| UniProt Related Accession: | Q18PE1 |
| Molecular Weight: | 63,938 Da |
| NCBI Full Name: | Protein Dok-7 |
| NCBI Synonym Full Names: | docking protein 7 |
| NCBI Official Symbol: | DOK7Â Â |
| NCBI Official Synonym Symbols: | CMS10; CMS1B; C4orf25Â Â |
| NCBI Protein Information: | protein Dok-7 |
| UniProt Protein Name: | Protein Dok-7 |
| UniProt Synonym Protein Names: | Downstream of tyrosine kinase 7 |
| Protein Family: | Protein |
| UniProt Gene Name: | DOK7Â Â |
| UniProt Entry Name: | DOK7_HUMAN |
| Antibodies | ELISA Kits |
| DOK7 Antibody (PACO03946) | DOK7 Colorimetric Cell-Based ELISA |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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