| UniProt Protein Function: | ECSM2: Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis via modulation of the actin cytoskeleton. Belongs to the ECSCR family.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 5q31.2Cellular Component: cytosol; plasma membraneBiological Process: negative regulation of angiogenesis |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is primarily found in endothelial cells and blood vessels, where it is involved in cell shape changes and EGF-induced cell migration. It can enhance the activation of vascular endothelial growth factor receptor-2/kinase insert domain receptor and also promote the proteolysis of internalized kinase insert domain receptor. This gene may play a role in angiogenesis-related diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014] |
| UniProt Code: | Q19T08 |
| NCBI GenInfo Identifier: | 121940639 |
| NCBI Gene ID: | 641700 |
| NCBI Accession: | Q19T08.1 |
| UniProt Secondary Accession: | Q19T08,B4E3H7, C3RSF2 |
| UniProt Related Accession: | Q19T08 |
| Molecular Weight: | 21,295 Da |
| NCBI Full Name: | Endothelial cell-specific chemotaxis regulator |
| NCBI Synonym Full Names: | endothelial cell surface expressed chemotaxis and apoptosis regulator |
| NCBI Official Symbol: | ECSCR |
| NCBI Official Synonym Symbols: | ARIA; ECSM2 |
| NCBI Protein Information: | endothelial cell-specific chemotaxis regulator |
| UniProt Protein Name: | Endothelial cell-specific chemotaxis regulator |
| UniProt Synonym Protein Names: | Apoptosis regulator through modulating IAP expression; ARIA; Endothelial cell-specific molecule 2 |
| Protein Family: | Endothelial cell-specific chemotaxis regulator |
| UniProt Gene Name: | ECSCR |
| UniProt Entry Name: | ECSCR_HUMAN |
