Bovine PF4 Recombinant Protein (RPPB1239)
- SKU:
- RPPB1239
- Product Type:
- Recombinant Protein
- Species:
- Bovine
- Uniprot:
- P02777
Description
| Product Name: | Bovine PF4 Recombinant Protein |
| Product Code: | RPPB1239 |
| Size: | 100µg |
| Species: | Bovine |
| Target: | PF4 |
| Synonyms: | CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2?m filtered concentrated solution in 20 mM PB and 500mM NaCl, pH 7.0. |
| Solubility: | It is recommended to reconstitute the lyophilized Platelet Factor-4 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized CXCL4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Platelet Factor-4 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | ESSFPATFVP LPADSEGGED EDLQCVCLKT TSGINPRHIS SLEVIGAGTH CPSPQLLATK KTGRKICLDQ QRPLYKKILK KLLDGDES |
| Biological Activity: | The biological activity determined by a chemotaxis bioassay using human neutrophils is 10-100ng/ml. |
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets.PF4�s major physiologic role appears to be neutralization of molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Furthermore, it is used as an inhibitor in the angiogenesis during tumor therapy.
Platelet Factor-4 (CXCL4) Bovine Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 88 amino acid and having a molecular mass of approximately 9.5kDa.PF4 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P02777 |
| NCBI GenInfo Identifier: | 130303 |
| NCBI Gene ID: | 507790 |
| NCBI Accession: | P02777.1 |
| UniProt Secondary Accession: | P02777 |
| UniProt Related Accession: | P02777 |
| Molecular Weight: | 9,523 Da |
| NCBI Full Name: | Platelet factor 4 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | PF4�� |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | platelet factor 4 |
| UniProt Protein Name: | Platelet factor 4 |
| UniProt Synonym Protein Names: | C-X-C motif chemokine 4 |
| Protein Family: | Platelet factor |
| UniProt Gene Name: | PF4�� |
| UniProt Entry Name: |
