Anti-GRIK1 Antibody (CAB10475)

Antibody Name:	Anti-GRIK1 Antibody
Antibody SKU:	CAB10475
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 859-918 of human GRIK1 (NP_000821.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 859-918 of human GRIK1 (NP_000821.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	YKSR KNND IEQA FCFF YGLQ CKQT HPTN STSG TTLS TDLE CGKL IREE RGIR KQSS VHTV
Gene ID:	2897
Uniprot:	P39086
Cellular Location:	Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Calculated MW:	102kDa/103kDa
Observed MW:	Refer to Figures

Synonyms:

GRIK1, EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5, kainate 1

Background:

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene.

UniProt Protein Function:	GluR5: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated Chromosomal Location of Human Ortholog: 21q22.11 Cellular Component: presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; plasma membrane; cell junction Molecular Function:extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity Biological Process: synaptic transmission, glutamatergic; nervous system development; regulation of synaptic transmission, glutamatergic; central nervous system development; glutamate signaling pathway; positive regulation of synaptic transmission, GABAergic; negative regulation of synaptic transmission, glutamatergic; regulation of inhibitory postsynaptic membrane potential; synaptic transmission; behavioral response to pain; transport; ionotropic glutamate receptor signaling pathway; adult behavior; regulation of excitatory postsynaptic membrane potential; positive regulation of gamma-aminobutyric acid secretion
NCBI Summary:	Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:	P39086
NCBI GenInfo Identifier:	729597
NCBI Gene ID:	2897
NCBI Accession:	P39086.1
UniProt Secondary Accession:	P39086,Q13001, Q86SU9,
UniProt Related Accession:	P39086
Molecular Weight:	102,631 Da
NCBI Full Name:	Glutamate receptor ionotropic, kainate 1
NCBI Synonym Full Names:	glutamate receptor, ionotropic, kainate 1
NCBI Official Symbol:	GRIK1
NCBI Official Synonym Symbols:	EAA3; EEA3; GLR5; GLUR5; GluK1
NCBI Protein Information:	glutamate receptor ionotropic, kainate 1; gluR-5; glutamate receptor 5; excitatory amino acid receptor 3
UniProt Protein Name:	Glutamate receptor ionotropic, kainate 1
UniProt Synonym Protein Names:	Excitatory amino acid receptor 3; EAA3; Glutamate receptor 5; GluR-5; GluR5
Protein Family:	Glutamate receptor ionotropic
UniProt Gene Name:	GRIK1
UniProt Entry Name:	GRIK1_HUMAN

Antibodies	ELISA Kits
GRIK1 Antibody (PACO03970)	GluR5 Colorimetric Cell-Based ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)