GRIK2 Antibody (PACO07184)
- SKU:
- PACO07184
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
| Antibody Name: | GRIK2 Antibody (PACO07184) |
| Antibody SKU: | PACO07184 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC-p:1:100-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic Peptide |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemical analysis of paraffin-embedded Human Colon Tissue using GRIK2(GluR6) Rabbit pAb diluted at 1:200. |
| UniProt Protein Function: | GluR6: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2. Defects in GRIK2 are the cause of mental retardation autosomal recessive type 6 (MRT6). It is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT6 patients display mild to severe mental retardation and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK2 subfamily. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, calcium; Channel, ligand-gated; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6q16.3 Cellular Component: dendrite cytoplasm; presynaptic membrane; postsynaptic membrane; kainate selective glutamate receptor complex; integral to plasma membrane; dendrite; postsynaptic density; plasma membrane; terminal button; perikaryon; cell junction Molecular Function:protein homodimerization activity; kainate selective glutamate receptor activity; extracellular-glutamate-gated ion channel activity; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; PDZ domain binding Biological Process: regulation of synaptic transmission; regulation of long-term neuronal synaptic plasticity; synaptic transmission, glutamatergic; behavioral fear response; glutamate signaling pathway; generation of action potential; negative regulation of synaptic transmission, glutamatergic; regulation of short-term neuronal synaptic plasticity; regulation of JNK cascade; receptor clustering; positive regulation of synaptic transmission; cellular calcium ion homeostasis; synaptic transmission; intracellular protein transport; regulation of inhibitory postsynaptic membrane potential; neuron apoptosis; ionotropic glutamate receptor signaling pathway; transport; positive regulation of neuron apoptosis; negative regulation of neuron apoptosis; regulation of excitatory postsynaptic membrane potential Disease: Mental Retardation, Autosomal Recessive 6 |
| NCBI Summary: | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive mental retardation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13002 |
| NCBI GenInfo Identifier: | 2492627 |
| NCBI Gene ID: | 2898 |
| NCBI Accession: | Q13002.1 |
| UniProt Secondary Accession: | Q13002,Q8WWS1, Q96KS6, Q96KS7, Q96KS8, A6NMY9, B5MCV0 D7RWZ3, D7RWZ4, D7RWZ5, D7RWZ6, D7RWZ7, |
| UniProt Related Accession: | Q13002 |
| Molecular Weight: | 908 |
| NCBI Full Name: | Glutamate receptor ionotropic, kainate 2 |
| NCBI Synonym Full Names: | glutamate receptor, ionotropic, kainate 2 |
| NCBI Official Symbol: | GRIK2Â Â |
| NCBI Official Synonym Symbols: | EAA4; GLR6; MRT6; GLUK6; GLUR6; GluK2Â Â |
| NCBI Protein Information: | glutamate receptor ionotropic, kainate 2; gluR-6; bA487F5.1; glutamate receptor 6; glutamate receptor form A; glutamate receptor form B; glutamate receptor form C; glutamate receptor form D; glutamate receptor form E; excitatory amino acid receptor 4 |
| UniProt Protein Name: | Glutamate receptor ionotropic, kainate 2 |
| UniProt Synonym Protein Names: | Excitatory amino acid receptor 4; EAA4; Glutamate receptor 6; GluR-6; GluR6 |
| Protein Family: | Glutamate receptor ionotropic |
| UniProt Gene Name: | GRIK2Â Â |
| UniProt Entry Name: | GRIK2_HUMAN |
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