HCRT Antibody (PACO18794)
- SKU:
- PACO18794
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | HCRT Antibody (PACO18794) |
| Antibody SKU: | PACO18794 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human HCRT |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18794(HCRT Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. |
| Synonyms: | hypocretin (orexin) neuropeptide precursor |
| UniProt Protein Function: | HCRT: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. Defects in HCRT are the cause of narcolepsy type 1 (NRCLP1). Narcolepsy is a neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, such as cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Human narcolepsy is associated with a deficient orexin system. Orexins are absent and/or greatly diminished in the brain and cerebrospinal fluid (CSF) of most narcoleptic patients. Belongs to the orexin family. |
| UniProt Protein Details: | Protein type:Hormone Chromosomal Location of Human Ortholog: 17q21 Cellular Component: synaptic vesicle; rough endoplasmic reticulum; perinuclear region of cytoplasm; extracellular region; cell junction; secretory granule Molecular Function:type 2 hypocretin receptor binding; type 1 hypocretin receptor binding Biological Process: synaptic transmission; elevation of cytosolic calcium ion concentration; negative regulation of transmission of nerve impulse; neuropeptide signaling pathway; eating behavior; negative regulation of DNA replication; negative regulation of potassium ion transport; protein kinase C activation; regulation of neurotransmitter secretion; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of calcium ion transport; regulation of excitatory postsynaptic membrane potential; positive regulation of transmission of nerve impulse Disease: Narcolepsy 1 |
| NCBI Summary: | This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010] |
| UniProt Code: | O43612 |
| NCBI GenInfo Identifier: | 4557635 |
| NCBI Gene ID: | 3060 |
| NCBI Accession: | NP_001515.1 |
| UniProt Related Accession: | O43612 |
| Molecular Weight: | 13,363 Da |
| NCBI Full Name: | orexin |
| NCBI Synonym Full Names: | hypocretin (orexin) neuropeptide precursor |
| NCBI Official Symbol: | HCRT |
| NCBI Official Synonym Symbols: | OX; PPOX; NRCLP1 |
| NCBI Protein Information: | orexin |
| UniProt Protein Name: | Orexin |
| UniProt Synonym Protein Names: | Hypocretin; Hcrt |
| UniProt Gene Name: | HCRT |
| UniProt Entry Name: | OREX_HUMAN |
| Antibodies | ELISA Kits |
| Anti-Orexin Antibody (CAB9821) | Human Orexin ELISA Kit |
| Human Orexin A ELISA Kit | |
| Human OXA (Orexin A) ELISA Kit (HUES02121) | |
| Human Orexin (HCRT) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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