Human ACOT11 Recombinant Protein (RPPB5776)
- SKU:
- RPPB5776
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8WXI4
- Research Area:
- Enzymes
Frequently bought together:
Description
| Product Name: | Human ACOT11 Recombinant Protein |
| Product Code: | RPPB5776 |
| Size: | 20µg |
| Species: | Human |
| Target: | ACOT11 |
| Synonyms: | Acyl-CoA Thioesterase 11, StAR-Related Lipid Transfer (START) Domain Containing 14, Thioesterase, Adipose Associated, Acyl-CoA Thioester Hydrolase 11, Adipose-Associated Thioesterase, Brown Fat-Inducible Thioesterase, Thioesterase Superfamily Member 1, START Domain Containing 14, Acyl-Coenzyme A Thioesterase 11, STARD14, THEM1, THEA, BFIT, BFIT1, BFIT2, KIAA0707, EC 3.1.2.1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ACOT11 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSNRTS RKSALRAGND SAMADGEGYR NPTEVQMSQL VLPCHTNQRG ELSVGQLLKW IDTTACLSAE RHAGCPCVTA SMDDIYFEHT ISVGQVVNIK AKVNRAFNSS MEVGIQVASE DLCSEKQWNV CKALATFVAR REITKVKLKQ ITPRTEEEKM EHSVAAERRR MRLVYADTIK DLLANCAIQG DLESRDCSRM VPAEKTRVES VELVLPPHAN HQGNTFGGQI MAWMENVA |
ACOT11 belongs to the acyl-CoA thioesterase family which catalyses the transformation of activated fatty acids to the equivalent non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and inhibited by high temperatures. Obesity-resistant mice demonstrated High levels of expression compared with obesity-prone mice, indicating BFIT takes part in acyl-CoA thioesterase 11 in obesity. BFIT has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.
ACOT11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain topological domain containing 268 amino acids (19-250 a.a) and having a molecular mass of 29.9kDa. ACOT11 is fused to a 36 amino acid His-tag at N-terminus.
| UniProt Protein Function: | ACOT11: Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Hydrolase; EC 3.1.2.-Chromosomal Location of Human Ortholog: 1p32.3Cellular Component: cytoplasmMolecular Function: acyl-CoA hydrolase activity; lipid bindingBiological Process: response to temperature stimulus; response to cold; fatty acid metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010] |
| UniProt Code: | Q8WXI4 |
| NCBI GenInfo Identifier: | 21363000 |
| NCBI Gene ID: | 26027 |
| NCBI Accession: | Q8WXI4.1 |
| UniProt Secondary Accession: | Q8WXI4,O75187, Q52LP1, Q53ER9, Q96DI1, Q9H883, B1AQ22 D3DQ50 |
| UniProt Related Accession: | Q8WXI4 |
| Molecular Weight: | 67,152 Da |
| NCBI Full Name: | Acyl-coenzyme A thioesterase 11 |
| NCBI Synonym Full Names: | acyl-CoA thioesterase 11 |
| NCBI Official Symbol: | ACOT11�� |
| NCBI Official Synonym Symbols: | BFIT; THEA; THEM1; STARD14�� |
| NCBI Protein Information: | acyl-coenzyme A thioesterase 11; START domain containing 14; acyl-CoA thioester hydrolase 11; adipose-associated thioesterase; brown fat-inducible thioesterase; thioesterase, adipose associated; thioesterase superfamily member 1; StAR-related lipid transfer (START) domain containing 14 |
| UniProt Protein Name: | Acyl-coenzyme A thioesterase 11 |
| UniProt Synonym Protein Names: | Acyl-CoA thioester hydrolase 11; Adipose-associated thioesterase; Brown fat-inducible thioesterase; BFIT |
| Protein Family: | Acyl-coenzyme A thioesterase |
| UniProt Gene Name: | ACOT11�� |
| UniProt Entry Name: | ACO11_HUMAN |
