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Human BPI Recombinant Protein (RPPB3045)

SKU:
RPPB3045
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P17213
€273
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Description

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Product Name:Human BPI Recombinant Protein
Product Code:RPPB3045
Size:10µg
Species:Human
Target:BPI
Synonyms:Bactericidal/permeability-increasing protein, CAP 57.
Formulation:BPI (1.15mg/ml) is supplied in 25mM Sodium Acetate pH-4.6.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles.
Purity:Greater than 70% as determined by SDS-PAGE and capillary electrophoresis.

BPI encodes a lipopolysaccharide binding protein. BPI is related to human neutrophil granules and has bactericidal activity on gram-negative organisms.

The native protein BPI is isolated from human buffy coats and has a molecular mass of�53kDa.

UniProt Protein Function:BPI: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
UniProt Protein Details:

Protein type:Cell surface; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q11.23

Cellular Component: integral to plasma membrane

Molecular Function:lipopolysaccharide binding

Biological Process: negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of macrophage activation; negative regulation of tumor necrosis factor production

NCBI Summary:This gene encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has antimicrobial activity against gram-negative organisms. [provided by RefSeq, Nov 2014]
UniProt Code:P17213
NCBI GenInfo Identifier:215274242
NCBI Gene ID:671
NCBI Accession:P17213.4
UniProt Secondary Accession:P17213,Q1ZZU8, Q5JRW0, Q8IW58, Q9BYZ9, Q9H1L2, Q9H1M8 Q9H203, Q9UCT4, Q9UD65, B2RCY2,
UniProt Related Accession:P17213
Molecular Weight:
NCBI Full Name:Bactericidal permeability-increasing protein
NCBI Synonym Full Names:bactericidal/permeability-increasing protein
NCBI Official Symbol:BPI��
NCBI Official Synonym Symbols:rBPI; BPIFD1��
NCBI Protein Information:bactericidal permeability-increasing protein
UniProt Protein Name:Bactericidal permeability-increasing protein
UniProt Synonym Protein Names:CAP 57
Protein Family:BPI fold-containing family
UniProt Gene Name:BPI��
UniProt Entry Name:BPI_HUMAN

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