Human ENO2 Recombinant Protein (RPPB1614)
- SKU:
- RPPB1614
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P09104
- Research Area:
- Enzymes
Description
| Product Name: | Human ENO2 Recombinant Protein |
| Product Code: | RPPB1614 |
| Size: | 25µg |
| Species: | Human |
| Target: | ENO2 |
| Synonyms: | Gamma-enolase, EC 4.2.1.11, 2-phospho-D-glycerate hydro-lyase, Neural enolase, Neuron-specific enolase, NSE, Enolase 2, ENO2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | Enolase 2 is supplied in 20mM Tris pH-7.5, 0.1M KCl, 5mM MgSO4. |
| Stability: | Store at 4°C if entire vial will be used within 1-2 weeks. Store, frozen at -20°C for longer periods of time. Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR DGDKQRYLGK GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT ENKSKFGANA ILGVSLAVCK AGAAERELPL YRHIAQLAGN SDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAESFRD AMRLGAEVYH TLKGVIKDKY GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI VIGMDVAASE FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV TEAIQACKLA QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEELGDE ARFAGHNFRN PSVL |
Neuron-specificenolase also caled NSE is a glycolytic isoenzyme which is situated in central and peripheral neurons and neuroendocrine cells. Enolase-2 is released into the CSF when neural tissue is injured. Neoplasms derived from neural or neuroendocrine tissue release Enolase-2 into the blood. Enolase-2 is a useful substance that has been detected in patients with certain tumors, such as neuroblastoma, small cell lung cancer, medullary thyroid cancer, carcinoid tumors, pancreatic endocrine tumors, and melanoma. ENO2 is 1 of the 3 enolase isoenzymes found in mammals. ENO2 isoenzyme, is found in mature neurons and cells of neuronal origin. An exchange from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.
ENO2 Human Recombinant expressed in E. coli contains 434 amino acids and its Mw is 47 kDa. The Enolase-2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ENO2: an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytosol; extracellular space; myelin sheath; perikaryon; phosphopyruvate hydratase complex; photoreceptor inner segment; plasma membrane Molecular Function:magnesium ion binding; phosphopyruvate hydratase activity; protein binding Biological Process: carbohydrate metabolic process; gluconeogenesis; glucose metabolic process |
| NCBI Summary: | This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09104 |
| NCBI GenInfo Identifier: | 20981682 |
| NCBI Gene ID: | 2026 |
| NCBI Accession: | P09104.3 |
| UniProt Secondary Accession: | P09104,Q96J33, B7Z2X9, |
| UniProt Related Accession: | P09104 |
| Molecular Weight: | 42,707 Da |
| NCBI Full Name: | Gamma-enolase |
| NCBI Synonym Full Names: | enolase 2 (gamma, neuronal) |
| NCBI Official Symbol: | ENO2�� |
| NCBI Official Synonym Symbols: | NSE; HEL-S-279�� |
| NCBI Protein Information: | gamma-enolase |
| UniProt Protein Name: | Gamma-enolase |
| UniProt Synonym Protein Names: | 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE |
| Protein Family: | Gamma-enolase |
| UniProt Gene Name: | ENO2�� |
| UniProt Entry Name: | ENOG_HUMAN |
