Human HSPB8 Recombinant Protein (RPPB5257)
- SKU:
- RPPB5257
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UJY1
Description
| Product Name: | Human HSPB8 Recombinant Protein |
| Product Code: | RPPB5257 |
| Size: | 10µg |
| Species: | Human |
| Target: | HSPB8 |
| Synonyms: | HSPB8, H11, HMN2, CMT2L, DHMN2, E2IG1, HMN2A, HSP22, Heat shock protein beta-8, Alpha-crystallin C chain, Small stress protein-like protein HSP22, E2-induced gene 1 protein, Protein kinase H11, CRYAC. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The HSPB8 protein solution contains 20mM Tris-HCl pH-8, 100mM NaCl, and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MADGQMPFSC HYPSRLRRDP FRDSPLSSRL LDDGFGMDPF PDDLTASWPD WALPRLSSAW PGTLRSGMVP RGPTATARFG VPAEGRTPPP FPGEPWKVCV NVHSFKPEEL MVKTKDGYVE VSGKHEEKQQ EGGIVSKNFT KKIQLPAEVD PVTVFASLSP EGLLIIEAPQ VPPYSTFGES SFNNELPQDS QEVTCT |
HSPB8 is part of the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. HSPB8 is induced by estrogen in estrogen receptor-positive breast cancer cells. HSPB8 protein functions as a chaperone in association with BAG3, a stimulator of macroautophagy. HSPB8 participates in the regulation of cell proliferation, apoptosis, and carcinogenesis. Mutations in HSPB8 gene have been related with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
HSPB8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 216 amino acids (1-196 a.a.) and having a molecular mass of 23.7kDa. The HSPB8 is fused to a 20 amino acid His Tag at N-terminus and purified by conventional chromatography.
| UniProt Protein Function: | HSPB8: Displays temperature-dependent chaperone activity. Monomer. Interacts with HSPB1. Interacts with DNAJB6. By 17-beta-estradiol. Predominantly expressed in skeletal muscle and heart. Belongs to the small heat shock protein (HSP20) family. |
| UniProt Protein Details: | Protein type:Heat shock protein Chromosomal Location of Human Ortholog: 12q24.23 Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; intracellular; nucleus Molecular Function:identical protein binding; protein binding; protein kinase activity Disease: Charcot-marie-tooth Disease, Axonal, Type 2l; Neuronopathy, Distal Hereditary Motor, Type Iia |
| NCBI Summary: | The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UJY1 |
| NCBI GenInfo Identifier: | 13431576 |
| NCBI Gene ID: | 26353 |
| NCBI Accession: | Q9UJY1.1 |
| UniProt Secondary Accession: | Q9UJY1,Q6FIH3, Q9UKS3, B2R6A6, |
| UniProt Related Accession: | Q9UJY1 |
| Molecular Weight: | 196 |
| NCBI Full Name: | Heat shock protein beta-8 |
| NCBI Synonym Full Names: | heat shock 22kDa protein 8 |
| NCBI Official Symbol: | HSPB8�� |
| NCBI Official Synonym Symbols: | H11; HMN2; CMT2L; DHMN2; E2IG1; HMN2A; HSP22�� |
| NCBI Protein Information: | heat shock protein beta-8; protein kinase H11; alpha-crystallin C chain; E2-induced gene 1 protein; heat shock 27kDa protein 8; small stress protein-like protein HSP22 |
| UniProt Protein Name: | Heat shock protein beta-8 |
| UniProt Synonym Protein Names: | Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22 |
| Protein Family: | Heat shock protein |
| UniProt Gene Name: | HSPB8�� |
| UniProt Entry Name: | HSPB8_HUMAN |
