Human IGF2 Recombinant Protein (RPPB0428)
- SKU:
- RPPB0428
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P01344
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human IGF2 Recombinant Protein |
| Product Code: | RPPB0428 |
| Size: | 50µg |
| Species: | Human |
| Target: | IGF2 |
| Synonyms: | Somatomedin-A, IGF2, INSIGF, pp9974, C11orf43, FLJ22066, FLJ44734. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein was lyophilized from a sterile filtered solution containing 0.1 % trifluoroacetic acid (TFA). |
| Solubility: | It is recommended to reconstitute the lyophilized IGF2 in sterile 18M?-cm H2O at a concentration of 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IGF-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGFII should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE |
| Biological Activity: | The activity is determined by the dose dependent proliferation of FDC-P1 cells and is typically 1.4 ng/mL corresponding to a specific activity of 7.1x105units/mg. |
IGF-2 is a member of the INS family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Insulin-Like Growth Factor- II Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 67 amino acids and having a molecular mass of 7.5k Dalton.������������������IGF-II is purified by proprietary chromatographic techniques.
| NCBI Summary: | This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010] |
| UniProt Code: | P01344 |
| NCBI GenInfo Identifier: | 124255 |
| NCBI Gene ID: | 3481 |
| NCBI Accession: | P01344.1 |
| UniProt Related Accession: | P01344 |
| Molecular Weight: | 11kDa |
| NCBI Full Name: | Insulin-like growth factor II |
| NCBI Synonym Full Names: | insulin like growth factor 2 |
| NCBI Official Symbol: | IGF2�� |
| NCBI Official Synonym Symbols: | GRDF; IGF-II; PP9974; C11orf43�� |
| NCBI Protein Information: | insulin-like growth factor II |
| UniProt Protein Name: | Insulin-like growth factor II |
| UniProt Synonym Protein Names: | Somatomedin-ACleaved into the following 3 chains:Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin |
| Protein Family: | Insulin-like growth factor |
| UniProt Gene Name: | IGF2�� |
| UniProt Entry Name: | IGF2_HUMAN |
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