Human KDSR Recombinant Protein (RPPB1857)
- SKU:
- RPPB1857
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q06136
- Research Area:
- Enzymes
Description
| Product Name: | Human KDSR Recombinant Protein |
| Product Code: | RPPB1857 |
| Size: | 20µg |
| Species: | Human |
| Target: | KDSR |
| Synonyms: | 3-ketodihydrosphingosine reductase, KDS reductase, 3-dehydrosphinganine reductase, Follicular variant translocation protein 1, FVT-1, KDSR, FVT1, DHSR, SDR35C1, FLJ36555, FLJ92680. |
| Source: | Escherichia Coli |
| Physical Appearance: | The�KDSR is supplied as a sterile filtered colorless solution. |
| Formulation: | The KDSR solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol, 0.1M NaCl and 0.1mM PMSF. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | KDSR purity was found to be greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MKPLALPGAH VVVTGGSSGI GKCIAIECYK QGAFITLVAR NEDKLLQAKK EIEMHSINDK QVVLCISVDV SQDYNQVENV IKQAQEKLGP VDMLVNCAGM AVSGKFEDLE VSTFERLMSI NYLGSVYPSR AVITTMKERR VGRIVFVSSQ AGQLGLFGFT AYSASKFAIR GLAEALQMEV KPYNVYITVA YPPDTDTPGF AEENRTKPLE TRLISETTSV CKPEQVAKQI VKDAIQGNFN SSLGSD |
3-ketodihydrosphingosine reductase (KDSR) is a 332 amino acid multi-pass membrane protein which localizes to the ER and is a member of the short-chain dehydrogenases/reductases (SDR) family. KDSR is a secreted protein that is weakly expressed in hematopoietic tissue. Furthermore, KDSR catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). The putative active site residues of KDSR are found on the cytosolic side of the endoplasmic reticulum membrane. Chromosomal rearrangement in the KDSR gene is a cause of follicular lymphoma, aka type II chronic lymphatic leukemia.
KDSR Human Recombinant fused with a�21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�266 amino acids (26-270 a.a.) and having a molecular mass of 29kDa. The KDSR is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q06136 |
| NCBI GenInfo Identifier: | 544358 |
| NCBI Gene ID: | 2531 |
| NCBI Accession: | Q06136.1 |
| UniProt Secondary Accession: | Q06136 |
| UniProt Related Accession: | Q06136 |
| Molecular Weight: | 29kDa |
| NCBI Full Name: | 3-ketodihydrosphingosine reductase |
| NCBI Synonym Full Names: | 3-ketodihydrosphingosine reductase |
| NCBI Official Symbol: | KDSR�� |
| NCBI Official Synonym Symbols: | DHSR; FVT1; EKVP4; SDR35C1�� |
| NCBI Protein Information: | 3-ketodihydrosphingosine reductase |
| UniProt Protein Name: | |
| UniProt Synonym Protein Names: | |
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