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Exenatide Recombinant Protein (RPPB1305)

SKU:
RPPB1305
Product Type:
Recombinant Protein
Uniprot:
P26349
Research Area:
Hormones
€1,289
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Description

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Product Name:Exenatide Recombinant Protein
Product Code:RPPB1305
Size:10mg
Target:Exenatide
Synonyms:Exendin-4.
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The Exenatide peptide was lyophilized from a concentrated solution with no additives.
Solubility:It is recommended to reconstitute the lyophilized Exenatide in sterile 18M?-cm H2O not less than 100 �g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized Exenatide although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Exenatide should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 99.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2

Exenatide Derived from the saliva of the gila monster, is a 39 amino acid peptide that mimics the GLP-1 incretin, an insulin secretagogue with glucoregulatory effects. Typical responses to exenatide include improvements in the initial rapid release of endogenous insulin, suppression of glucagon release by the pancreas, regulation of gastric empyting, and reduced appetite - all of which function to lower blood glucose. Exenatide is self-regulating in that it lowers blood sugar when levels are elevated but does not continue to lower blood sugar when levels return to normal, unlike with sulfonylureas or insulins.

Exenatide is a single, non-glycosylated, peptide containing 39 amino acids and having a molecular mass of 4186.6 Dalton. Exenatide has the empirical formula C184H282N50O60S.

UniProt Protein Function:Venom protein that mimics the incretin hormone glucagon-like peptide 1 (GLP-1). It stimulates insulin synthesis and secretion, protects against beta-cell apoptosis in response to different insults, and promotes beta-cell proliferation. It also promotes satiety, reduces food intake, reduces fat deposition, reduces body weight and inhibits gastric emptying. Interacts with GLP-1 receptor (GLP1R). Induces hypotension that is mediated by relaxation of cardiac smooth muscle.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P26349
NCBI GenInfo Identifier:2851623
NCBI Gene ID:
NCBI Accession:P26349.2
UniProt Secondary Accession:P26349
UniProt Related Accession:P26349
Molecular Weight:
NCBI Full Name:Exendin-4
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Exendin-4
UniProt Synonym Protein Names:INN: Exenatide
Protein Family:
UniProt Gene Name:
UniProt Entry Name:EXE4_HELSU

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