Human TFF2 Recombinant Protein (RPPB0963)
- SKU:
- RPPB0963
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q03403
- Research Area:
- Cytokines
Description
| Product Name: | Human TFF2 Recombinant Protein |
| Product Code: | RPPB0963 |
| Size: | 20µg |
| Species: | Human |
| Target: | TFF2 |
| Synonyms: | TFF-2, Spasmolytic polypeptide, Spasmolysin, SML1, Trefoil factor 2, SP, TFF2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The TFF2 protein was lyophilized from 0.4?m filtered solution at a concentration of 0.5mg/ml containing 20mM Tris pH-7.5, and 20mM NaCl. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Lyophilized TFF2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TFF2 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSV TGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECAS RKCCFSNFIF EVPWCFFPKSVEDCHY |
Proteins of the TFF family are characterized by obtaining a minimum of 1 copy of the trefoil motif, a 40-amino acid domain that contains 3 conserved disulfides. Trefoil Factors are stable secretory proteins expressed in gastrointestinal mucosa which protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium.TFF2 inhibits gastric acid motility & secretion. TFF2 stabilizes glycoproteins in the mucus gel through interactions with carbohydrate side chains.
TFF-2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 116 amino acids (24-129) which includes a 10 amino acid His Tag fused at N-terminus and having a total molecular mass of 13.2 kDa. TFF2 Human Recombinant is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TFF2: Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: extracellular space Molecular Function:protein binding Biological Process: digestion; wound healing |
| NCBI Summary: | Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q03403 |
| NCBI GenInfo Identifier: | 2833194 |
| NCBI Gene ID: | 7032 |
| NCBI Accession: | Q03403.2 |
| UniProt Secondary Accession: | Q03403,Q15854, |
| UniProt Related Accession: | Q03403 |
| Molecular Weight: | 14,284 Da |
| NCBI Full Name: | Trefoil factor 2 |
| NCBI Synonym Full Names: | trefoil factor 2 |
| NCBI Official Symbol: | TFF2�� |
| NCBI Official Synonym Symbols: | SP; SML1�� |
| NCBI Protein Information: | trefoil factor 2 |
| UniProt Protein Name: | Trefoil factor 2 |
| UniProt Synonym Protein Names: | Spasmolysin; Spasmolytic polypeptide; SP |
| Protein Family: | Splenin |
| UniProt Gene Name: | TFF2�� |
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