Human SMS Recombinant Protein (RPPB2276)
- SKU:
- RPPB2276
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P52788
- Research Area:
- Enzymes
Description
| Product Name: | Human SMS Recombinant Protein |
| Product Code: | RPPB2276 |
| Size: | 10µg |
| Species: | Human |
| Target: | SMS |
| Synonyms: | Spermine synthase, SPMSY, Spermidine aminopropyltransferase, SMS, SRS, SpS, MRSR. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The SMS solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAAARH STLDFMLGAK ADGETILKGL QSIFQEQGMA ESVHTWQDHG YLATYTNKNG SFANLRIYPH GLVLLDLQSY DGDAQGKEEI DSILNKVEER MKELSQDSTG RVKRLPPIVR GGAIDRYWPT ADGRLVEYDI DEVVYDEDSP YQNIKILHSK QFGNILILSG DVNLAESDLA YTRAIMGSGK EDYTGKDVLI LGGGDGGILC EIVKLKPKMV TMVEIDQMVI DGCKKYMRKT CGDVLDNLKG DCYQVLIEDC IPVLKRYAKE GREFDYVIND LTAVPISTSP EEDSTWEFLR LILDLSMKVL KQDGKYFTQG NCVNLTEALS LYEEQLGRLY CPVEFSKEIV CVPSYLELWV FYTVWKKAKP |
Spermine synthase (SMS) is amember of the spermidine/spermine synthase family. SMS is an enzyme which converts spermidine into spermine. The SMS enzyme is essential for normal viability, growth and fertility involved in polyamine metabolism. Defects in the SMS gene are the cause of Snyder-Robinson syndrome (SRS), also known as X-linked mental retardation Snyder-Robinson type. SRS is categorized by moderate intellectual deficit, hypotonia, an unsteady gait, osteoporosis, kyphoscoliosis and facial asymmetry, its transmission is X-linked recessive.
SMS Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 390 amino acids (1-366) and having a molecular mass of 43.8kDa.SMS is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SMS: an ubiquitous enzyme of polyamine metabolism. Synthesizes spermine from spermidine. |
| UniProt Protein Details: | Protein type:Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - arginine and proline; EC 2.5.1.22; Transferase; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - glutathione Chromosomal Location of Human Ortholog: Xp22.1 Cellular Component: cytosol Molecular Function:spermidine synthase activity; spermine synthase activity Biological Process: methionine metabolic process; spermine biosynthetic process; polyamine metabolic process Disease: Mental Retardation, X-linked, Syndromic, Snyder-robinson Type |
| NCBI Summary: | This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] |
| UniProt Code: | P52788 |
| NCBI GenInfo Identifier: | 21264341 |
| NCBI Gene ID: | 6611 |
| NCBI Accession: | NP_004586 |
| UniProt Secondary Accession: | P52788,O00544, Q9UQS1, A6NHA7, A6NI34, B2R9M0, |
| UniProt Related Accession: | P52788 |
| Molecular Weight: | 35,278 Da |
| NCBI Full Name: | spermine synthase isoform 1 |
| NCBI Synonym Full Names: | spermine synthase |
| NCBI Official Symbol: | SMS�� |
| NCBI Official Synonym Symbols: | SRS; SpS; MRSR; SPMSY�� |
| NCBI Protein Information: | spermine synthase |
| UniProt Protein Name: | Spermine synthase |
| UniProt Synonym Protein Names: | Spermidine aminopropyltransferase |
| UniProt Gene Name: | SMS�� |
| UniProt Entry Name: | SPSY_HUMAN |
