Human Uteroglobin, His Tag Recombinant Protein (CPRT0898)

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CPRT0898
€278

Description

Data SheetMSDS

SCGB1A1 Human, His Recombinant Protein

Name:SCGB1A1 Human, His
Synonyms:Uteroglobin, Clara cell phospholipid-bindingprotein, CCPBP, Clara cells 10 kDa secretory protein, CC10, Secretoglobin family 1A member 1, Urinary protein 1, UP-1, UP1, Urine protein 1, SCGB1A1, CCSP, UGB, CC16.
Introduction:Uteroglobin (SCGB1A1) which belongs to the Secretoglobin (SCGBs) superfamily, is a multifunctional protein that exerts anti–inflammatory and anti–tumorigenic effects by bindingsmall hydrophobic molecules such as phospholipids and prostaglandins. Uteroglobin is involved in numerous functions includinganti–inflammation, inhibition of phospholipase A2 and the sequesteringof hydrophobic ligands. SCGB1A1 is expressed by Clara cells, the non–ciliated, non–mucous secretory cells predominant in lungbronchioles, and by other epithelia which communicate with the external environment. On top of sequesteringpro–inflammatory mediators and carcinogens, Uteroglobin is implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation. SCGB1A1 gene defects are associated with a susceptibility to asthma.
Description:Uteroglobin Human Recombinant produced in E.Coli is a single, non–glycosylated, polypeptide chain containing 80 amino acids and includinga 10 a.a N–terminal His tag. The total molecular mass is 9.2kDa (calculated).
Source:Escherichia Coli.
Pack size:10µg
Physical Appearance:Filtered White lyophilized (freeze–dried) powder.
Formulation:Filtered (0.4 µm) and lyophilized from 0.5 mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.
Solubility:It is recommended to add 200µl deionized water to prepare a workingstock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. SCGB1A1 is not sterile! Please filter the product by an appropriate sterile filter before usingit in the cell culture.
Stability:Store lyophilized protein at –20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawingcycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 90.0% as determined by SDS–PAGE.
Amino Acid Sequence:MKHHHHHHASEICPSFQRVI ETLLMDTPSS YEAAMELFSP DQDMREAGAQ LKKLVDTLPQ KPRESIIKLM EKIAQSSLCN.
Biological Activity:N/A
Usage:Assay Genie’s products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Uniprot:P11684

SCGB1A1 Human, His Recombinant Protein - Protein Information

UniProt Protein Function:SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.
UniProt Protein Details:

Protein type:Secreted; Cell cycle regulation; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: extracellular space; rough endoplasmic reticulum; nuclear envelope; secretory granule

Molecular Function:protein binding; phospholipase A2 inhibitor activity

Biological Process: response to drug; negative regulation of interleukin-4 production; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of mRNA stability; response to xenobiotic stimulus; response to silicon dioxide; negative regulation of interleukin-13 production; negative regulation of T cell proliferation; response to ozone; negative regulation of interferon-gamma production; response to cytokine stimulus; negative regulation of catalytic activity; regulation of inflammatory response; negative regulation of interleukin-5 production; embryo implantation

Disease: Asthma, Susceptibility To

NCBI Summary:This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
UniProt Code:P11684
NCBI GenInfo Identifier:112672
NCBI Gene ID:7356
NCBI Accession:P11684.1
UniProt Related Accession:P11684
Molecular Weight:16kDa
NCBI Full Name:Uteroglobin
NCBI Synonym Full Names:secretoglobin family 1A member 1
NCBI Official Symbol:SCGB1A1  
NCBI Official Synonym Symbols:UGB; UP1; CC10; CC16; CCSP; UP-1; CCPBP  
NCBI Protein Information:uteroglobin
UniProt Protein Name:Uteroglobin
UniProt Synonym Protein Names:Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; UP-1; UP1; Urine protein 1
Protein Family:Uteroglobin
UniProt Gene Name:SCGB1A1  
UniProt Entry Name:UTER_HUMAN
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Additional Information

Product type:
Recombinant Protein
Reactivity:
Human
Host Species:
E.Coli
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