Human TIMP4 Recombinant Protein (RPPB2328)
- SKU:
- RPPB2328
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q99727
- Research Area:
- Enzymes
Description
| Product Name: | Human TIMP4 Recombinant Protein |
| Product Code: | RPPB2328 |
| Size: | 5µg |
| Species: | Human |
| Target: | TIMP4 |
| Synonyms: | TIMP Metallopeptidase Inhibitor 4, Tissue Inhibitor OfMetalloproteinases 4, Tissue Inhibitor Of Metalloproteinase 4, TIMP-4,Metalloproteinase Inhibitor 4. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TIMP4 protein solution (0.25mg/ml) contains PhosphateBuffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPCSCAPAH PQQHICHSAL VIRAKISSEK VVPASADPAD TEKMLRYEIK QIKMFKGFEK VKDVQYIYTP FDSSLCGVKL EANSQKQYLL TGQVLSDGKV FIHLCNYIEP WEDLSLVQRE SLNHHYHLNC GCQITTCYTV PCTISAPNEC LWTDWLLERK LYGYQAQHYV CMKHVDGTCS WYRGHLPLRK EFVDIVQPHH HHHH |
Metalloproteinase inhibitor 4 (TIMP4) is a member of a family of secreted proteins which regulate the activation and proteolytic activity of the zinc enzymes known as matrix metalloproteinases. The four known members of this family are TIMP1, 2, 3 and 4. TIMP4 is produced by various tissues, particularly the brain, heart, ovary and skeletal muscle. Limited studies have shown that the TIMP4 protein has a tumor suppressive effect against Wilm92s tumor, exhibiting a negative correlation with glioma malignancy and is found in breast carcinoma cells.
TIMP4 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 204 amino acids (30-224 a.a.) andhaving a molecular mass of 23.5kDa (Molecular size on SDS-PAGE will appear atapproximately 18-28kDa).�TIMP4 is expressed with a 6 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TIMP4: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9. Belongs to the protease inhibitor I35 (TIMP) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3p25 Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere Molecular Function:metal ion binding; metalloendopeptidase inhibitor activity; protease binding Biological Process: central nervous system development; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; Notch signaling pathway; ovulation cycle; response to cytokine stimulus; response to drug; response to lipopolysaccharide; response to organic substance; response to peptide hormone stimulus |
| NCBI Summary: | This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99727 |
| NCBI GenInfo Identifier: | 3915135 |
| NCBI Gene ID: | 7079 |
| NCBI Accession: | Q99727.1 |
| UniProt Secondary Accession: | Q99727,B2R7K6, |
| UniProt Related Accession: | Q99727 |
| Molecular Weight: | 25,503 Da |
| NCBI Full Name: | Metalloproteinase inhibitor 4 |
| NCBI Synonym Full Names: | TIMP metallopeptidase inhibitor 4 |
| NCBI Official Symbol: | TIMP4�� |
| NCBI Protein Information: | metalloproteinase inhibitor 4 |
| UniProt Protein Name: | Metalloproteinase inhibitor 4 |
| UniProt Synonym Protein Names: | Tissue inhibitor of metalloproteinases 4; TIMP-4 |
| Protein Family: | Metalloproteinase inhibitor |
| UniProt Gene Name: | TIMP4�� |
| UniProt Entry Name: | TIMP4_HUMAN |
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