Human TSPAN7 Recombinant Protein (RPPB5032)
- SKU:
- RPPB5032
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P41732
Description
| Product Name: | Human TSPAN7 Recombinant Protein |
| Product Code: | RPPB5032 |
| Size: | 10µg |
| Species: | Human |
| Target: | TSPAN7 |
| Synonyms: | Tspan-7, Cell surface glycoprotein A15, Membrane component chromosome X surface marker 1, T-cell acute lymphoblastic leukemia-associated antigen 1, TALLA-1, Transmembrane 4 superfamily member 2, CD231, A15, DXS1692E, MXS1, TM4SF2. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | TSPAN7 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPRHEIKDT FLRTYTDAMQ TYNGNDERSR AVDHVQRSLS CCGVQNYTNW STSPYFLEHG IPPSCCMNET DCNPQDLHNL TVAATKVNQK GCYDLVTSFM ETNMHHHHHH |
Tetraspanin 7, also known as TSPAN7, is part of the transmembrane 4 superfamily, which is also familiar as the tetraspanin family. Most of these proteins mediate signal transduction events which play a role in the regulation of cell development, activation, growth as well as motility. Furthermore, TSPAN7 is associated with X-linked mental retardation in addition to neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. Lately, TSPAN7 has been acknowledged as a key immune system target in type 1 diabetes.
TSPAN7 Human Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 110 amino acids (113-213a.a.) and having a molecular mass of 12.6kDa. (Molecular size on SDS-PAGE under reducing conditions 13.5-18kDa). TSPAN7 is expressed with a 6amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TSPAN7: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. These proteins apparently mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Defects in TSPAN7 are the cause of mental retardation X- linked type 58 (MRX58). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: integral to plasma membrane Biological Process: viral reproduction Disease: Mental Retardation, X-linked 58 |
| NCBI Summary: | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked mental retardation and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P41732 |
| NCBI GenInfo Identifier: | 17380550 |
| NCBI Gene ID: | 7102 |
| NCBI Accession: | P41732.2 |
| UniProt Secondary Accession: | P41732,Q8WVG5, Q9UEY9, B2R5W7, D3DWB1, |
| UniProt Related Accession: | P41732 |
| Molecular Weight: | 27kDa |
| NCBI Full Name: | Tetraspanin-7 |
| NCBI Synonym Full Names: | tetraspanin 7 |
| NCBI Official Symbol: | TSPAN7�� |
| NCBI Official Synonym Symbols: | A15; MXS1; CD231; MRX58; CCG-B7; TM4SF2; TALLA-1; TM4SF2b; DXS1692E�� |
| NCBI Protein Information: | tetraspanin-7; tspan-7; CD231 antigen; tetraspanin protein; transmembrane protein A15; cell surface glycoprotein A15; transmembrane 4 superfamily 2b; transmembrane 4 superfamily member 2; membrane component chromosome X surface marker 1; membrane component, X chromosome, surface marker 1; T-cell acute lymphoblastic leukemia associated antigen 1; T-cell acute lymphoblastic leukemia-associated antigen 1 |
| UniProt Protein Name: | Tetraspanin-7 |
| UniProt Synonym Protein Names: | Cell surface glycoprotein A15; Membrane component chromosome X surface marker 1; T-cell acute lymphoblastic leukemia-associated antigen 1; TALLA-1; Transmembrane 4 superfamily member 2; CD_antigen: CD231 |
| UniProt Gene Name: | TSPAN7�� |
| UniProt Entry Name: | TSN7_HUMAN |
