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Low Endotoxin Purified Anti-Human IL-4 Antibody [MP4-25D2] (AGEL2053)

SKU:
AGEL2053
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
€229 - €1,219
Frequently bought together:

Description

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Product Title:Low Endotoxin Purified Anti-Human IL-4 Antibody [MP4-25D2]
SKU:AGEL2053
Size:50µg, 500µg, 1mg
Clone No:MP4-25D2
Synonyms:Interleukin-4;IL-4;B-cell IgG differentiation factor;B-cell growth factor 1;BSF-1;IGG1 induction factor;
Host Species:Rat
Reactivity:Human
Application:ICFCM;Neut
Isotype:Rat IgG1, κ
Isotype Control:AF/LE Purified Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by ELISA assay. Purified MP4-25D2 has been tested by blocking fluorochrome conjugated MP4-25D2 for intracellular cytokine staining. In order to obtain complete blocking results, a saturated amount of purified antibody (≤ 5.0 µg/million cells) should be used for incubation with target cells, prior to staining with fluorochrome conjugated antibody. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P05112
Gene ID:3565
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

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