null

Anti-MYST1 Antibody (CAB2208)

SKU:
CAB2208
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-MYST1 Antibody CAB2208
  • Epigenetics and Nuclear Signaling Antibodies 3 Anti-MYST1 Antibody CAB2208
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MYST1 Antibody
Antibody SKU:CAB2208
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human MYST1 (NP_892003.2).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:100 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:OVCAR3, NIH/3T3
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human MYST1 (NP_892003.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAQ GAAA AVAA GTSG VAGE GEPG PGEN AAAE GTAP SPGR VSPP TPAR GEPE VTVE IGET YLCR RPDS TWHS AEVI QSRV NDQE GREE FYVH YVGF NRRL DEWV DKNR LALT KTVK DAVQ KNSE KYLS ELAE QPER KITR NQKR KHDE INHV QKTY AEMD PTTA ALEK EHEA ITKV KYVD KIHI GNYE IDAW YFSP FPED
Gene ID:84148
Uniprot:Q9H7Z6
Cellular Location:Chromosome, Nucleus
Calculated MW:52kDa/53kDa
Observed MW:58kDa
Synonyms:KAT8, MOF, MYST1, ZC2HC8, hMOF
Background:This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:MYST1: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Belongs to the MYST (SAS/MOZ) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: kinetochore; nucleoplasm; nuclear membrane; nucleus; histone acetyltransferase complex

Molecular Function:protein binding; histone acetyltransferase activity; enzyme binding; metal ion binding; acetyltransferase activity; histone acetyltransferase activity (H4-K16 specific); transcription factor binding; methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; regulation of autophagy; histone acetylation; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:Q9H7Z6
NCBI GenInfo Identifier:68565938
NCBI Gene ID:84148
NCBI Accession:Q9H7Z6.2
UniProt Related Accession:Q9H7Z6
Molecular Weight:
NCBI Full Name:Histone acetyltransferase KAT8
NCBI Synonym Full Names:lysine acetyltransferase 8
NCBI Official Symbol:KAT8  
NCBI Official Synonym Symbols:MOF; hMOF; MYST1; ZC2HC8  
NCBI Protein Information:histone acetyltransferase KAT8
UniProt Protein Name:Histone acetyltransferase KAT8
UniProt Synonym Protein Names:Lysine acetyltransferase 8; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; MYST-1; hMOF
Protein Family:Males-absent on the first protein
UniProt Gene Name:KAT8  
UniProt Entry Name:KAT8_HUMAN
Anti-MYST1 Antibody (CAB2208)Western blot analysis of extracts of various cell lines, using KAT8 antibody (CAB2208) at 1:3000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s.
Anti-MYST1 Antibody (CAB2208)Immunofluorescence analysis of U-2 OS cells using MYST1 Polyclonal Antibody (CAB2208) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Related Products