KCNN2 Rabbit Polyclonal Antibody

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SKU:
CAB10662
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Description

Technical Manual

KCNN2 Rabbit Polyclonal Antibody

Product Name:KCNN2 Rabbit Polyclonal Antibody
Product SKU:CAB10662
Size:20uL, 50 uL
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Background:

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 520-579 of human KCNN2 (NP_067627.2).
Sequence:

SIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS

Gene ID:3781
Swiss Prot:Q9H2S1
Synonyms:KCNN2; KCa2.2; SK2; SKCA2; SKCa 2; hSK2; SKCa2
Calculated MW:26kDa/63kDa
Observed MW:Refer to figures
Reactivity:Human
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Application Key:Western blotting 
Positive Samples:
Cellular Location:Membrane, Multi-pass membrane protein

Uniprot Information

UniProt Protein Function:KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q22.3

Cellular Component: cell soma; cell surface; dendritic spine; integral to membrane; plasma membrane; smooth endoplasmic reticulum; T-tubule; Z disc

Molecular Function:alpha-actinin binding; calcium-activated potassium channel activity; calmodulin binding; protein domain specific binding; protein homodimerization activity; small conductance calcium-activated potassium channel activity

Biological Process: potassium ion transport

NCBI Summary:Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
UniProt Code:Q9H2S1
NCBI GenInfo Identifier:25777645
NCBI Gene ID:3781
NCBI Accession:NP_067627.2
UniProt Secondary Accession:Q9H2S1,Q0VFZ4, Q6PJI0, Q6X2Y2, A6NF94,
UniProt Related Accession:Q9H2S1
Molecular Weight:26,341 Da
NCBI Full Name:small conductance calcium-activated potassium channel protein 2 isoform a
NCBI Synonym Full Names:potassium calcium-activated channel subfamily N member 2
NCBI Official Symbol:KCNN2 
NCBI Official Synonym Symbols:SK2; hSK2; SKCA2; KCa2.2; SKCa 2 
NCBI Protein Information:small conductance calcium-activated potassium channel protein 2
UniProt Protein Name:Small conductance calcium-activated potassium channel protein 2
UniProt Synonym Protein Names:KCa2.2
Protein Family:Small conductance calcium-activated potassium channel protein
UniProt Gene Name:KCNN2 
UniProt Entry Name:KCNN2_HUMAN
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Additional Information

Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
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