KL Antibody (PACO48534)
- SKU:
- PACO48534
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | KL Antibody (PACO48534) |
| Antibody SKU: | PACO48534 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Klotho protein (34-981AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO48534 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO48534 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using PACO48534 at dilution of 1:100. |
| Background: | May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). |
| Synonyms: | Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide], KL |
| UniProt Protein Function: | Klotho: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Hydrolase; EC 3.2.1.31 Chromosomal Location of Human Ortholog: 13q12 Cellular Component: extracellular region; integral to plasma membrane; plasma membrane Molecular Function:1-phosphatidylinositol-3-kinase activity; beta-glucosidase activity; fibroblast growth factor binding; fibroblast growth factor receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; Ras guanyl-nucleotide exchange factor activity Biological Process: aging; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; phosphoinositide-mediated signaling; positive regulation of bone mineralization; regulation of phosphoinositide 3-kinase cascade Disease: Tumoral Calcinosis, Hyperphosphatemic, Familial |
| NCBI Summary: | This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UEF7 |
| NCBI GenInfo Identifier: | 77416517 |
| NCBI Gene ID: | 9365 |
| NCBI Accession: | Q9UEF7.2 |
| UniProt Secondary Accession: | Q9UEF7,Q5VZ95, Q96KV5, Q96KW5, Q9UEI9, Q9Y4F0, |
| UniProt Related Accession: | Q9UEF7 |
| Molecular Weight: | 62,135 Da |
| NCBI Full Name: | Klotho |
| NCBI Synonym Full Names: | klotho |
| NCBI Official Symbol: | KL |
| NCBI Protein Information: | klotho |
| UniProt Protein Name: | Klotho |
| Protein Family: | Klotho |
| UniProt Gene Name: | KL |
| UniProt Entry Name: | KLOT_HUMAN |
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