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Anti-LRPAP1 Antibody (CAB13026)

SKU:
CAB13026
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 3 Anti-LRPAP1 Antibody CAB13026
  • Cell Biology Antibodies 3 Anti-LRPAP1 Antibody CAB13026
€139 - €419
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Description

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Antibody Name:Anti-LRPAP1 Antibody
Antibody SKU:CAB13026
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-357 of human LRPAP1 (NP_002328.1).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HeLa, A375
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 35-357 of human LRPAP1 (NP_002328.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:YSRE KNQP KPSP KRES GEEF RMEK LNQL WEKA QRLH LPPV RLAE LHAD LKIQ ERDE LAWK KLKL DGLD EDGE KEAR LIRN LNVI LAKY GLDG KKDA RQVT SNSL SGTQ EDGL DDPR LEKL WHKA KTSG KFSG EELD KLWR EFLH HKEK VHEY NVLL ETLS RTEE IHEN VISP SDLS DIKG SVLH SRHT ELKE KLRS INQG LDRL RRVS HQGY STEA EFEE PRVI DLWD LAQS ANLT DKEL EAFR EELK HFEA KIEK HNHY QKQL EIAH EKLR HAES VGDG ERVS RSRE KHAL LEGR TKEL GYTV KKHL QDLS GRIS RARH NEL
Gene ID:4043
Uniprot:P30533
Cellular Location:Cell surface, Cytoplasm, Endoplasmic reticulum
Calculated MW:41kDa
Observed MW:42kDa
Synonyms:LRPAP1, A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP
Background:This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:LRPAP1: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330. In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis. Belongs to the alpha-2-MRAP family.
UniProt Protein Details:

Protein type:Receptor, misc.

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: cell surface; endoplasmic reticulum; extracellular region; plasma membrane; integral to membrane; vesicle

Molecular Function:heparin binding; receptor antagonist activity; protein binding; low-density lipoprotein receptor binding; unfolded protein binding; asialoglycoprotein receptor activity

Biological Process: vesicle-mediated transport; receptor-mediated endocytosis; protein folding; negative regulation of protein binding

Disease: Myopia 23, Autosomal Recessive

NCBI Summary:This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
UniProt Code:P30533
NCBI GenInfo Identifier:231539
NCBI Gene ID:4043
NCBI Accession:P30533.1
UniProt Related Accession:P30533
Molecular Weight:
NCBI Full Name:Alpha-2-macroglobulin receptor-associated protein
NCBI Synonym Full Names:LDL receptor related protein associated protein 1
NCBI Official Symbol:LRPAP1  
NCBI Official Synonym Symbols:RAP; MRAP; A2RAP; HBP44; MYP23; A2MRAP; alpha-2-MRAP  
NCBI Protein Information:alpha-2-macroglobulin receptor-associated protein
UniProt Protein Name:Alpha-2-macroglobulin receptor-associated protein
UniProt Synonym Protein Names:Low density lipoprotein receptor-related protein-associated protein 1; RAP
UniProt Gene Name:LRPAP1  
UniProt Entry Name:AMRP_HUMAN
Anti-LRPAP1 Antibody (CAB13026)Western blot analysis of extracts of various cell lines, using LRPAP1 antibody (CAB13026) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-LRPAP1 Antibody (CAB13026)Immunofluorescence analysis of U-2 OS cells using LRPAP1 Rabbit pAb (CAB13026) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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