Mouse CTSS Recombinant Protein (RPPB1523)
- SKU:
- RPPB1523
- Product Type:
- Recombinant Protein
- Species:
- Mouse
- Uniprot:
- O70370
- Research Area:
- Enzymes
Description
| Product Name: | Mouse CTSS Recombinant Protein |
| Product Code: | RPPB1523 |
| Size: | 10µg |
| Species: | Mouse |
| Target: | CTSS |
| Synonyms: | Cathepsin S, Ctss, Cats. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | CTSS protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | VAMEQLQRDP TLDYHWDLWK KTHEKEYKDK NEEEVRRLIW EKNLKFIMIH NLEYSMGMHT YQVGMNDMGD MTNEEISCRM GALRISRQSP KTVTFRSYSN RTLPDTVDWR EKGCVTEVKY QGSCGACWAF SAVGALEGQL KLKTGKLISL SAQNLVDCSN EEKYGNKGCG GGYMTEAFQY IIDNGGIEAD ASYPYKAMDE KCHYNSKNRA ATCSRYIQLP FGDEDALKEA VATKGPVSVG IDASHSSFFF YKSGVYDDPS CTGNVNHGVL VVGYGTLDGK DYWLVKNSWG LNFGDQGYIR MARNNKNHCG IASYCSYPEI LEHHHHHHDY WLVKNSWGLN FGDQGYIRMA RNNKNHCGIASYCSYPEILE HHHHHH |
Cathepsin S (CTSS) belongs to the peptidase C1 family. CTSS is a lysosomal cysteine proteinase that participates in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. CTSS functions as an elastase over a broad pH range in alveolar macrophages.
CTSS Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 328 amino acids (21-340 a.a.) and having a molecular mass of 37.2kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions).CTSS is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.27; Protease Chromosomal Location of Human Ortholog: 3 F2.1|3 40.74 cM Cellular Component: cell surface; extracellular space; intracellular membrane-bound organelle; lysosome; membrane Molecular Function:collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; laminin binding; peptidase activity; proteoglycan binding Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen; bone resorption; collagen catabolic process; immune response; positive regulation of inflammatory response; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; regulation of sensory perception of pain; response to acidity |
| NCBI Summary: | This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, which encode preproproteins that are proteolytically processed to generate mature protein products. This enzyme is secreted by antigen-presenting cells during inflammation and may induce pain and itch via activation of G-protein coupled receptors. Homozygous knockout mice for this gene exhibit impaired wound healing, reduced tumorigenesis in a pancreatic cancer model, and reduced pathogenesis in a myasthenia gravis model. [provided by RefSeq, Aug 2015] |
| UniProt Code: | O70370 |
| NCBI GenInfo Identifier: | 510025483 |
| NCBI Gene ID: | 13040 |
| NCBI Accession: | NP_067256.4 |
| UniProt Secondary Accession: | O70370,O54973, E9QK18, |
| UniProt Related Accession: | O70370 |
| Molecular Weight: | 27.8kD |
| NCBI Full Name: | cathepsin S isoform 2 preproprotein |
| NCBI Synonym Full Names: | cathepsin S |
| NCBI Official Symbol: | Ctss�� |
| NCBI Official Synonym Symbols: | Cats�� |
| NCBI Protein Information: | cathepsin S |
| UniProt Protein Name: | Cathepsin S |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | Ctss�� |
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