Human TGFB3 Recombinant Protein (RPPB0978)
- SKU:
- RPPB0978
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10600
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human TGFB3 Recombinant Protein |
| Product Code: | RPPB0978 |
| Size: | 1ug |
| Species: | Human |
| Target: | TGFB3 |
| Synonyms: | Transforming Growth Factor-beta3, TGFB3, ARVD, FLJ16571, TGF-beta3. |
| Source: | HEK293 Cells |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The TGF-b�3 was lyophilized from 1mg/ml in 1xPBS. |
| Solubility: | It is recommended to reconstitute the lyophilized TGF-b 3 in sterile 4mM HCl containing 0.1% endotoxin-free recombinant HSA. |
| Stability: | Lyophilized TGF-b�3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TGF-b�3 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95% as obsereved by SDS-PAGE. |
| Biological Activity: | The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2) and is typically 0.1-0.5ng/ml. |
Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.
TGF-b 3 Human Recombinant produced in HEK cells is a non-glycosylated homodimer, having a total molecular weight of 25kDa.The TGF-b 3 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. |
| UniProt Protein Details: | Protein type:Ligand, receptor tyrosine kinase; Motility/polarity/chemotaxis; Secreted; Cell development/differentiation; Secreted, signal peptide Chromosomal Location of Human Ortholog: 14q24 Cellular Component: extracellular matrix; extracellular region; extracellular space; plasma membrane Molecular Function:cytokine activity; identical protein binding; protein binding; punt binding; transforming growth factor beta binding Biological Process: alveolus development; in utero embryonic development; intercellular junction assembly and maintenance; mammary gland development; negative regulation of cell proliferation; negative regulation of DNA replication; negative regulation of neuron apoptosis; palate development; platelet degranulation; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of DNA replication; positive regulation of filopodium formation; positive regulation of protein secretion; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of cell proliferation; regulation of MAPKKK cascade; response to hypoxia; response to progesterone stimulus; salivary gland morphogenesis; transforming growth factor beta receptor signaling pathway; uterine wall breakdown Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome |
| NCBI Summary: | This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P10600 |
| NCBI GenInfo Identifier: | 135684 |
| NCBI Gene ID: | 7043 |
| NCBI Accession: | P10600.1 |
| UniProt Secondary Accession: | P10600,Q8WV88, |
| UniProt Related Accession: | P10600 |
| Molecular Weight: | 35,708 Da |
| NCBI Full Name: | Transforming growth factor beta-3 |
| NCBI Synonym Full Names: | transforming growth factor beta 3 |
| NCBI Official Symbol: | TGFB3�� |
| NCBI Official Synonym Symbols: | ARVD; LDS5; RNHF; ARVD1; TGF-beta3�� |
| NCBI Protein Information: | transforming growth factor beta-3 |
| UniProt Protein Name: | Transforming growth factor beta-3 |
| Protein Family: | Transforming growth factor |
| UniProt Gene Name: | TGFB3�� |
| UniProt Entry Name: | TGFB3_HUMAN |
