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Anti-MUSK Antibody (CAB2591)

SKU:
CAB2591
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Rabbit
Isotype:
IgG
€139 - €419
Frequently bought together:

Description

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Antibody Name:Anti-MUSK Antibody
Antibody SKU:CAB2591
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 424-783 of human MUSK (NP_001159752.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SW480
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 424-783 of human MUSK (NP_001159752.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LTIT TLYC CRRR KQWK NKKR ESAA VTLT TLPS ELLL DRLH PNPM YQRM PLLL NPKL LSLE YPRN NIEY VRDI GEGA FGRV FQAR APGL LPYE PFTM VAVK MLKE EASA DMQA DFQR EAAL MAEF DNPN IVKL LGVC AVGK PMCL LFEY MAYG DLNE FLRS MSPH TVCS LSHS DLSM RAQV SSPG PPPL SCAE QLCI ARQV AAGM AYLS ERKF VHRD LATR NCLV GENM VVKI ADFG LSRN IYSA DYYK ANEN DAIP IRWM PPES IFYN RYTT ESDV WAYG VVLW EIFS YGLQ PYYG MAHE EVIY YVRD GNIL SCPE NCPV ELYN LMRL CWSK LPAD RPSF TSIH RILE RMCE RAEG TVSV
Gene ID:4593
Uniprot:O15146
Cellular Location:Cell junction, Single-pass type I membrane protein, postsynaptic cell membrane, synapse
Calculated MW:86kDa/87kDa/97kDa
Observed MW:97kDa
Synonyms:MUSK, CMS9, FADS
Background:This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.
UniProt Protein Function:MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.
UniProt Protein Details:

Protein type:Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; Musk family

Chromosomal Location of Human Ortholog: 9q31.3-q32

Cellular Component: postsynaptic membrane; integral to plasma membrane; neuromuscular junction; cell junction; receptor complex

Molecular Function:protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; positive regulation of neuron apoptosis; protein amino acid autophosphorylation; multicellular organismal development; regulation of synaptic growth at neuromuscular junction; positive regulation of protein amino acid phosphorylation; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; memory; neuromuscular junction development

Disease: Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency; Fetal Akinesia Deformation Sequence

NCBI Summary:This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
UniProt Code:O15146
NCBI GenInfo Identifier:50400806
NCBI Gene ID:4593
NCBI Accession:O15146.1
UniProt Secondary Accession:O15146,Q32MJ8, Q32MJ9, Q5VZW7, Q5VZW8,
UniProt Related Accession:O15146
Molecular Weight:86,425 Da
NCBI Full Name:Muscle, skeletal receptor tyrosine-protein kinase
NCBI Synonym Full Names:muscle, skeletal, receptor tyrosine kinase
NCBI Official Symbol:MUSK  
NCBI Protein Information:muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor
UniProt Protein Name:Muscle, skeletal receptor tyrosine-protein kinase
UniProt Synonym Protein Names:Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor
Protein Family:Muskelin
UniProt Gene Name:MUSK  
UniProt Entry Name:MUSK_HUMAN
Anti-MUSK Antibody (CAB2591)Western blot analysis of extracts of SW480 cells, using MUSK antibody (CAB2591) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.

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