Anti-NABP2 Antibody (CAB18488)

Antibody Name:	Anti-NABP2 Antibody
Antibody SKU:	CAB18488
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant protein of human NABP2.

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:

Immunogen:	Recombinant protein of human NABP2.
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	79035
Uniprot:	Q9BQ15
Cellular Location:
Calculated MW:
Observed MW:	Refer to figures

Synonyms:	OBFC2B, SOSS-B1, SSB1, hSSB1, NABP2
Background:

UniProt Protein Function:	OBFC2B: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:DNA repair, damage; Cell cycle regulation Chromosomal Location of Human Ortholog: 12q13.3 Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus Molecular Function:enzyme binding; protein binding; single-stranded DNA binding Biological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; regulation of telomerase activity; response to DNA damage stimulus; response to ionizing radiation; snRNA transcription from RNA polymerase II promoter
NCBI Summary:	Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
UniProt Code:	Q9BQ15
NCBI GenInfo Identifier:	74761196
NCBI Gene ID:	79035
NCBI Accession:	Q9BQ15.1
UniProt Secondary Accession:	Q9BQ15,Q6XYC8, A6NDF8,
UniProt Related Accession:	Q9BQ15
Molecular Weight:	11,493 Da
NCBI Full Name:	SOSS complex subunit B1
NCBI Synonym Full Names:	nucleic acid binding protein 2
NCBI Official Symbol:	NABP2
NCBI Official Synonym Symbols:	SSB1; hSSB1; OBFC2B; SOSS-B1
NCBI Protein Information:	SOSS complex subunit B1
UniProt Protein Name:	SOSS complex subunit B1
UniProt Synonym Protein Names:	Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1
Protein Family:	SOSS complex
UniProt Gene Name:	NABP2
UniProt Entry Name:	SOSB1_HUMAN

Antibodies

NABP2 Antibody (PACO10988)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)