NES Antibody, HRP conjugated (PACO49023)
- SKU:
- PACO49023
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
| Antibody Name: | NES Antibody, HRP conjugated (PACO49023) |
| Antibody SKU: | PACO49023 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Nestin protein (1321-1569AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | HRP |
| Background: | Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). |
| Synonyms: | Nestin, NES |
| UniProt Protein Function: | nestin: an intermediate filament protein. It is expressed predominantly in stem cells of the central nervous system in the neural tube. Upon terminal neural differentiation, nestin is downregulated and replaced by neurofilaments. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: intermediate filament cytoskeleton; cytoplasm; intermediate filament Molecular Function:intermediate filament binding; structural molecule activity Biological Process: positive regulation of intermediate filament depolymerization; central nervous system development; negative regulation of catalytic activity; cell projection morphogenesis; brain development; negative regulation of neuron apoptosis; negative regulation of protein binding; G2/M transition of mitotic cell cycle; embryonic camera-type eye development |
| NCBI Summary: | This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011] |
| UniProt Code: | P48681 |
| NCBI GenInfo Identifier: | 146345464 |
| NCBI Gene ID: | 10763 |
| NCBI Accession: | P48681.2 |
| UniProt Secondary Accession: | P48681,O00552, Q3LIF5, Q5SYZ6, |
| UniProt Related Accession: | P48681 |
| Molecular Weight: | 1621 |
| NCBI Full Name: | Nestin |
| NCBI Synonym Full Names: | nestin |
| NCBI Official Symbol: | NES |
| NCBI Official Synonym Symbols: | Nbla00170 |
| NCBI Protein Information: | nestin |
| UniProt Protein Name: | Nestin |
| Protein Family: | Nestin |
| UniProt Gene Name: | NES |
| UniProt Entry Name: | NEST_HUMAN |
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