Anti-NFE2L2 Antibody (RACO0462)
- SKU:
- RACO0462
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- IF
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Product Name: | NFE2L2 Antibody |
| Product SKU: | RACO0462 |
| Size: | 50ul |
| Host Species: | Homo sapiens (Human) |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | IF:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | A synthesized peptide derived from human Nrf2 |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | Affinity-chromatography |
| Clonality: | Monoclonal |
| Isotype: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| Background: | Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region. |
| Synonyms: | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2), NFE2L2, NRF2 |
 | Immunofluorescence staining of Hela Cells with RACO0462 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L). |
| UniProt Protein Function: | NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: centrosome; cytoplasm; cytosol; nucleus; plasma membrane Molecular Function:DNA binding; protein binding; protein domain specific binding; transcription factor activity Biological Process: positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; transcription from RNA polymerase II promoter; unfolded protein response |
| NCBI Summary: | This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q16236 |
| NCBI GenInfo Identifier: | 25453452 |
| NCBI Gene ID: | 4780 |
| NCBI Accession: | Q16236.3 |
| UniProt Secondary Accession: | Q16236,Q53RW6, Q59HH2, Q96F71, B2RBU2, B4E338, E9PGJ7 |
| UniProt Related Accession: | Q16236 |
| Molecular Weight: | 65,356 Da |
| NCBI Full Name: | Nuclear factor erythroid 2-related factor 2 |
| NCBI Synonym Full Names: | nuclear factor, erythroid 2 like 2 |
| NCBI Official Symbol: | NFE2L2 |
| NCBI Official Synonym Symbols: | NRF2; HEBP1 |
| NCBI Protein Information: | nuclear factor erythroid 2-related factor 2 |
| UniProt Protein Name: | Nuclear factor erythroid 2-related factor 2 |
| UniProt Synonym Protein Names: | HEBP1; Nuclear factor, erythroid derived 2, like 2 |
| UniProt Gene Name: | NFE2L2 |
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