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Anti-GYS1 Antibody (CAB2519)

SKU:
CAB2519
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-GYS1 Antibody CAB2519
  • Metabolism Antibodies 2 Anti-GYS1 Antibody CAB2519
  • Metabolism Antibodies 2 Anti-GYS1 Antibody CAB2519
€139 - €419
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Description

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Antibody Name:Anti-GYS1 Antibody
Antibody SKU:CAB2519
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 488-737 of human GYS1 (NP_002094.2).
Application:WB IHC IF
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, 293T, BT-474, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 488-737 of human GYS1 (NP_002094.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLPV DYEE FVRG CHLG VFPS YYEP WGYT PAEC TVMG IPSI STNL SGFG CFME EHIA DPSA YGIY ILDR RFRS LDDS CSQL TSFL YSFC QQSR RQRI IQRN RTER LSDL LDWK YLGR YYMS ARHM ALSK AFPE HFTY EPNE ADAA QGYR YPRP ASVP PSPS LSRH SSPH QSED EEDP RNGP LEED GERY DEDE EAAK DRRN IRAP EWPR RASC TSST SGSK RNSV DTAT SSSL STPS EPLS PTSS LGEE RN
Gene ID:2997
Uniprot:P13807
Cellular Location:
Calculated MW:76kDa/83kDa
Observed MW:100kDa
Synonyms:GYS1, GSY, GYS
Background:The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1, 4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:GYS1: muscle glycogen synthase 1. Transfers glucosyl residue from UDP-glucose to glycogen. Regulated allosterically by glucose-6-phosphate, and by PKA-mediated phosphorylation.
UniProt Protein Details:

Protein type:Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: membrane; cytoplasm; inclusion body; cytosol

Molecular Function:protein binding; glycogen (starch) synthase activity; protein kinase binding; glucose binding

Biological Process: glycogen biosynthetic process; heart development; carbohydrate metabolic process; glucose metabolic process; pathogenesis

Disease: Glycogen Storage Disease 0, Muscle

NCBI Summary:The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
UniProt Code:P13807
NCBI GenInfo Identifier:1351366
NCBI Gene ID:2997
NCBI Accession:P13807.2
UniProt Secondary Accession:P13807,Q9BTT9,
UniProt Related Accession:P13807
Molecular Weight:737
NCBI Full Name:Glycogen
NCBI Synonym Full Names:glycogen synthase 1 (muscle)
NCBI Official Symbol:GYS1  
NCBI Official Synonym Symbols:GSY; GYS  
NCBI Protein Information:glycogen [starch] synthase, muscle; glycogen [starch] synthase, muscle
UniProt Protein Name:Glycogen [starch] synthase, muscle
Protein Family:Glycogen [starch] synthase
UniProt Gene Name:GYS1  
UniProt Entry Name:GYS1_HUMAN
Anti-GYS1 Antibody (CAB2519)Western blot analysis of extracts of various cell lines, using GYS1 antibody (CAB2519) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-GYS1 Antibody (CAB2519)Immunohistochemistry of paraffin-embedded human stomach cancer using GYS1 antibody (CAB2519) at dilution of 1:200 (40x lens).
Anti-GYS1 Antibody (CAB2519)Immunofluorescence analysis of HeLa cells using GYS1 antibody (CAB2519). Blue: DAPI for nuclear staining.

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