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Anti-PDGFRB Antibody (CAB1444)

SKU:
CAB1444
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CD140B
IBGC4
IMF1
JTK12
KOGS
PDGFR
PDGFR-1
PDGFR1
PENTT
PDGF Receptor beta
PDGFRB
PDGFR beta
$167 - $503
Frequently bought together:

Description

Product Name:PDGFRB Rabbit pAb
Product Code:CAB1444
Size:100uL
Synonyms:CD140B, IBGC4, IMF1, JTK12, KOGS, PDGFR, PDGFR-1, PDGFR1, PENTT, PDGF Receptor beta, PDGFRB, PDGFR beta
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic Peptide of human PDGFRB
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:1000 IHC 1:20 - 1:50 IF 1:20 - 1:50
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, NIH/3T3, C6
Immunogen:A synthetic Peptide of human PDGFRB
Purification Method:Affinity purification
Storage:Store at 4°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:5159
Uniprot:P09619
Cellular Location:Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein
Calculated MW:37kDa/123kDa
Observed MW:190kDa
UniProt Protein Function:PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.
UniProt Protein Details:

Protein type:EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: apical plasma membrane; cytoplasm; focal adhesion; intrinsic to plasma membrane; membrane; nucleus; plasma membrane

Molecular Function:enzyme binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; platelet activating factor receptor activity; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor activity; platelet-derived growth factor receptor binding; protein binding; protein kinase binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding

Biological Process: cardiac myofibril assembly; cell migration; MAPKKK cascade; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphoinositide-mediated signaling; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of phosphoprotein phosphatase activity; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of phosphoinositide 3-kinase cascade; signal transduction

Disease: Basal Ganglia Calcification, Idiopathic, 1; Basal Ganglia Calcification, Idiopathic, 4; Kosaki Overgrowth Syndrome; Myeloproliferative Disorder, Chronic, With Eosinophilia; Myofibromatosis, Infantile, 1; Premature Aging Syndrome, Penttinen Type

NCBI Summary:This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
UniProt Code:P09619
NCBI GenInfo Identifier:129890
NCBI Gene ID:5159
NCBI Accession:P09619.1
UniProt Secondary Accession:P09619,Q8N5L4, B5A957,
UniProt Related Accession:P09619
Molecular Weight:Calculated: 37kDa/123kDaObserved: 170kDa
NCBI Full Name:Platelet-derived growth factor receptor beta
NCBI Synonym Full Names:platelet derived growth factor receptor beta
NCBI Official Symbol:PDGFRB  
NCBI Official Synonym Symbols:IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1  
NCBI Protein Information:platelet-derived growth factor receptor beta
UniProt Protein Name:Platelet-derived growth factor receptor beta
UniProt Synonym Protein Names:Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-derived growth factor receptor 1; PDGFR-1; CD_antigen: CD140b
Protein Family:Platelet-derived growth factor receptor
UniProt Gene Name:PDGFRB  

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