Human VTA1 Recombinant Protein (RPPB5139)
- SKU:
- RPPB5139
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NP79
Description
| Product Name: | Human VTA1 Recombinant Protein |
| Product Code: | RPPB5139 |
| Size: | 20µg |
| Species: | Human |
| Target: | VTA1 |
| Synonyms: | Vacuolar protein sorting-associated protein VTA1 homolog, DRG-1, LYST-interacting protein 5, LIP5, SKD1-binding protein 1, SBP1, VTA1, C6orf55, DRG1My012, HSPC228. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | VTA1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 10% glycerol and 200mM NaCl. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMAALAP LPPLPAQFKS IQHHLRTAQE HDKRDPVVAY YCRLYAMQTG MKIDSKTPEC RKFLSKLMDQ LEALKKQLGD NEAITQEIVG CAHLENYALK MFLYADNEDR AGRFHKNMIK SFYTASLLID VITVFGELTD ENVKHRKYAR WKATYIHNCL KNGETPQAGP VGIEEDNDIE ENEDAGAASL PTQPTQPSSS STYDPSNMPS GNYTGIQIPP GAHAPANTPA EVPHSTGVAS NTIQPTPQTI PAIDPALFNT ISQGDVRLTP EDFARAQKYC KYAGSALQYE DVSTAVQNLQ KALKLLTTGR E |
Vps20-associated 1 homolog (VTA1) is a member of the VTA1 family. The VTA1 protein is involved in the endosomal multivesicular bodies (MVB) pathway. Furthermore, VTA1 is interacts with CHMP1B, CHMP2A, CHMP5, VPS4B, KIAA0174 (IST1) and possibly CHMP3. VTA1 is believed to be a cofactor of VPS4A/B, which catalyzes membrane-associated ESCRT-III assemblies. In addition, VTA1 is involved in the sorting and down-regulation of EGFR and also in HIV-1 budding.
VTA1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 331 amino acids (1-307 a.a.) and having a molecular mass of 36.5kDa.VTA1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VTA1: Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HIV-1 budding. Belongs to the VTA1 family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 6q24.1 Cellular Component: endosome membrane; cytosol Molecular Function:protein binding Biological Process: protein transport; viral reproduction; viral infectious cycle; endosome transport |
| NCBI Summary: | C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 15644320]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9NP79 |
| NCBI GenInfo Identifier: | 30580379 |
| NCBI Gene ID: | 51534 |
| NCBI Accession: | Q9NP79.1 |
| UniProt Related Accession: | Q9NP79 |
| Molecular Weight: | |
| NCBI Full Name: | Vacuolar protein sorting-associated protein VTA1 homolog |
| NCBI Synonym Full Names: | vesicle trafficking 1 |
| NCBI Official Symbol: | VTA1�� |
| NCBI Official Synonym Symbols: | DRG1; LIP5; SBP1; DRG-1; My012; C6orf55; HSPC228�� |
| NCBI Protein Information: | vacuolar protein sorting-associated protein VTA1 homolog |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein VTA1 homolog |
| UniProt Synonym Protein Names: | Dopamine-responsive gene 1 protein; DRG-1; LYST-interacting protein 5; LIP5; SKD1-binding protein 1; SBP1 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VTA1�� |
| UniProt Entry Name: | VTA1_HUMAN |
