Recombinant Human 4BB/TNFRSF9 Protein (His & Fc Tag) (RPES2781)

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SKU:
RPES2781
€499

Description

ELISA Kit Technical Manual

Recombinant Human 4BB/TNFRSF9 Protein (His & Fc Tag)

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Additional Information

Background:CD137 (also known as 4BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4BB signaling either by binding to 4BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials.
Name:Recombinant Human 4BB/TNFRSF9 Protein (His & Fc Tag)
Size:100µg
Assay Genie SKU:RPES2781
Synonyms:CD137; ILA; TNFRSF9; 4BB ligand receptor; CDw137; T-cell antigen 4BB homolog; T-cell antigen ILA
Species:Human
Expression host:HEK293 Cells
Sequence:Met 1-Gln 186
Accession:NP_001552.2
Mol Mass:45.2 kDa
AP Mol Mass:60-65 kDa
Tag:C-His & Fc
Purity:> 95 % as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per µg as determined by the LAL method.
Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8? for 2-7 days. Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from sterile PBS, pH 7.4
Reconstitution:Please refer to the printed manual for detailed information.
Product type:
Recombinant Protein
Host species:
HEK293 Cells
Reactivity:
Human
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