Description
Background
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes
Information | Description |
Product Name: | Recombinant Human Cathepsin B/CTSB Protein (His Tag) |
Size: | 10µg |
SKU: | RPES0033 |
Activity: | |
Synonym: | Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB |
Protein Construction: | Recombinant Human Cathepsin B is produced by our Mammalian expression system and the target gene encoding Arg18-Ile339 is expressed with a 6His tag at the C-terminus. |
Sequence: | Arg18-Ile339 |
Fusion tag: | C-6His |
Accession: | P07858 |
Species: | Human |
Expressed Host: | Human Cells |
Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
Purity: | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin: | < 1.0 EU per µg as determined by the LAL method. |
Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Mol Mass: | 36.9 kDa |
AP Mol Mass: | 40 kDa |
Formulation: | Supplied as a 0.2 uM filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
Reconstitution: | Please refer to the printed manual for detailed information. |