Recombinant Human Uteroglobin/SCGB1A1 Protein (His Tag) (RPES3832)

SKU:
RPES3832
€95

Description

ELISA Kit Technical Manual

Recombinant Human Uteroglobin/SCGB1A1 Protein (His Tag)

Background:Uteroglobin is a small, non-glycosylated secreted protein of the secretoglobin superfamily. It is produced by the non-ciliated, non-mucous secretory cells that predominate in lung bronchioles (Clara cells), and other non-ciliated epithelia that communicate with the external environment. Expression is induced by steroid hormones such as estrogen, and enhanced by the non-steroid hormone prolactin. Human Uteroglobin cDNA encodes a 21 amino acid (aa) signal sequence and a 70 aa mature protein. The mature protein forms a disulfide-linked head-to-tail homodimer of 16 kDa. This homodimer is thought to form a binding pocket that binds hydrophobic ligands such as phospholipids, progesterone and retinols. Binding of fibronectin to Uteroglobin in the kidney is thought to protect against nephropathy, while binding of the lipocalin receptor has been reported to suppress cancer cell motility and invasion.
Name:Recombinant Human Uteroglobin/SCGB1A1 Protein (His Tag)
Size:10µg
Assay Genie SKU:RPES3832
Synonyms:Uteroglobin; Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; UP; UP1; Urine protein 1; SCGB1A1; CCSP; UGB
Species:Human
Expression host:Human Cells
Sequence:Glu22-Asn91
Accession:P11684
Mol Mass:8.7 kDa
AP Mol Mass:9 kDa
Tag:C-His
Purity:> 95% as determined by reducing SDS-PAGE.
Endotoxin:< 1.0 EU per ?g as determined by the LAL method.
Storage:Lyophilized protein should be stored at < -20'C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7? for 2-7 days.Aliquots of reconstituted samples are stable at < -20'C for 3 months.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
Reconstitution:Please refer to the printed manual for detailed information.
UniProt Protein Function:SCGB1A1: Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. Belongs to the secretoglobin family.
UniProt Protein Details:

Protein type:Secreted; Cell cycle regulation; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: extracellular space; rough endoplasmic reticulum; nuclear envelope; secretory granule

Molecular Function:protein binding; phospholipase A2 inhibitor activity

Biological Process: response to drug; negative regulation of interleukin-4 production; response to glucocorticoid stimulus; response to lipopolysaccharide; female pregnancy; negative regulation of transcription from RNA polymerase II promoter; signal transduction; regulation of mRNA stability; response to xenobiotic stimulus; response to silicon dioxide; negative regulation of interleukin3 production; negative regulation of T cell proliferation; response to ozone; negative regulation of interferon-gamma production; response to cytokine stimulus; negative regulation of catalytic activity; regulation of inflammatory response; negative regulation of interleukin-5 production; embryo implantation

Disease: Asthma, Susceptibility To

NCBI Summary:This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
UniProt Code:P11684
NCBI GenInfo Identifier:112672
NCBI Gene ID:7356
NCBI Accession:P11684.1
UniProt Related Accession:P11684
Molecular Weight:16kDa
NCBI Full Name:Uteroglobin
NCBI Synonym Full Names:secretoglobin family 1A member 1
NCBI Official Symbol:SCGB1A1  
NCBI Official Synonym Symbols:UGB; UP1; CC10; CC16; CCSP; UP; CCPBP  
NCBI Protein Information:uteroglobin
UniProt Protein Name:Uteroglobin
UniProt Synonym Protein Names:Clara cell phospholipid-binding protein; CCPBP; Clara cells 10 kDa secretory protein; CC10; Secretoglobin family 1A member 1; Urinary protein 1; UP; UP1; Urine protein 1
Protein Family:Uteroglobin
UniProt Gene Name:SCGB1A1  
UniProt Entry Name:UTER_HUMAN
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Additional Information

Product type:
Recombinant Protein
Host species:
Human Cells
Reactivity:
Human
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