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Anti-ROR2 Antibody (CAB17331)

SKU:
CAB17331
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
€139 - €419
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Description

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Antibody Name:Anti-ROR2 Antibody
Antibody SKU:CAB17331
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human ROR2 (NP_004551.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Rat
Positive Samples:Rat small intestine
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human ROR2 (NP_004551.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CMRI GIPA ERLG RYHQ CYNG SGMD YRGT ASTT KSGH QCQP WALQ HPHS HHLS STDF PELG GGHA YCRN PGGQ MEGP WCFT QNKN VRME LCDV PSCS PRDS S
Gene ID:4920
Uniprot:Q01974
Cellular Location:Cell membrane, Single-pass type I membrane protein
Calculated MW:104kDa
Observed MW:145kDa
Synonyms:ROR2, BDB, BDB1, NTRKR2
Background:The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
UniProt Protein Function:ROR2: a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
UniProt Protein Details:

Protein type:Protein kinase, TK; Membrane protein, integral; Kinase, protein; Protein kinase, tyrosine (receptor); EC 2.7.10.1; TK group; Ror family

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:Wnt-protein binding; protein binding; frizzled binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: somitogenesis; inner ear morphogenesis; peptidyl-tyrosine phosphorylation; Wnt receptor signaling pathway, planar cell polarity pathway; multicellular organismal development; positive regulation of transcription, DNA-dependent; signal transduction; negative regulation of cell proliferation; Wnt receptor signaling pathway, calcium modulating pathway; JNK cascade; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; cartilage condensation; embryonic genitalia morphogenesis; positive regulation of cell migration

Disease: Robinow Syndrome, Autosomal Recessive; Brachydactyly, Type B1

NCBI Summary:The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
UniProt Code:Q01974
NCBI GenInfo Identifier:90110767
NCBI Gene ID:4920
NCBI Accession:Q01974.2
UniProt Secondary Accession:Q01974,Q59GF5, Q5SPI5, Q9HAY7, Q9HB61,
UniProt Related Accession:Q01974
Molecular Weight:943
NCBI Full Name:Tyrosine-protein kinase transmembrane receptor ROR2
NCBI Synonym Full Names:receptor tyrosine kinase-like orphan receptor 2
NCBI Official Symbol:ROR2  
NCBI Official Synonym Symbols:BDB; BDB1; NTRKR2  
NCBI Protein Information:tyrosine-protein kinase transmembrane receptor ROR2; neurotrophic tyrosine kinase receptor-related 2
UniProt Protein Name:Tyrosine-protein kinase transmembrane receptor ROR2
UniProt Synonym Protein Names:Neurotrophic tyrosine kinase, receptor-related 2
UniProt Gene Name:ROR2  
UniProt Entry Name:ROR2_HUMAN
Anti-ROR2 Antibody (CAB17331)Western blot analysis of extracts of rat small intestine, using ROR2 antibody (CAB17331) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.

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