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Anti-SAE1 Antibody (CAB0891)

SKU:
CAB0891
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
AOS1
HSPC140
SUA1
UBLE1A
€139 - €419
Frequently bought together:

Description

Product Name:SAE1 Rabbit mAb
Product Code:CAB0891
Size:20uL, 50uL, 100uL
Synonyms:AOS1, HSPC140, SUA1, UBLE1A
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human SAE1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, MCF7, DU145, Mouse testis, Mouse thymus, Rat testis
Immunogen:A synthesized peptide derived from human SAE1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:10055
Uniprot:Q9UBE0
Calculated MW:38kDa
Observed MW:40kDa
UniProt Protein Function:UBLE1A: The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.
UniProt Protein Details:

Protein type:Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytosol; nucleoplasm; nucleus

Molecular Function:ATP-dependent protein binding; enzyme activator activity; protein binding; protein C-terminus binding; protein heterodimerization activity; SUMO activating enzyme activity; ubiquitin activating enzyme activity

Biological Process: protein sumoylation; protein ubiquitination; regulation of mitotic cell cycle

NCBI Summary:Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]
UniProt Code:Q9UBE0
NCBI GenInfo Identifier:42559897
NCBI Gene ID:10055
NCBI Accession:Q9UBE0.1
UniProt Secondary Accession:Q9UBE0,O95717, Q9P020, B2RDP5, B3KMQ2, F5GXX7, G3XAK6
UniProt Related Accession:Q9UBE0
Molecular Weight:33,063 Da
NCBI Full Name:SUMO-activating enzyme subunit 1
NCBI Synonym Full Names:SUMO1 activating enzyme subunit 1
NCBI Official Symbol:SAE1  
NCBI Official Synonym Symbols:AOS1; SUA1; UBLE1A; HSPC140  
NCBI Protein Information:SUMO-activating enzyme subunit 1
UniProt Protein Name:SUMO-activating enzyme subunit 1
UniProt Synonym Protein Names:Ubiquitin-like 1-activating enzyme E1A
Protein Family:SUMO-activating enzyme
UniProt Gene Name:SAE1  
UniProt Entry Name:SAE1_HUMAN

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