| UniProt Protein Function: | SIN3A: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Interacts with BAZ2A, MXD3, MXD4, MBD2, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1 and SMYD2. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with ARID4B, BRMS1L, DACH1, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ, SUDS3 and TOPORS. Interacts with TET1; the interaction recruits SIN3A to gene promoters. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase. |
| UniProt Protein Details: | Protein type:Nucleolus; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: kinetochore; nucleoplasm; transcription factor complex; intercellular bridge; Sin3 complex; transcriptional repressor complex; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; protein deacetylase activity; protein complex binding; chromatin binding; histone deacetylase activity; transcription factor activity Biological Process: positive regulation of chromatin silencing; transcription, DNA-dependent; in utero embryonic development; rhythmic process; histone deacetylation; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; response to organic nitrogen; regulation of gene expression, epigenetic; protein amino acid deacetylation; negative regulation of gene expression, epigenetic; response to methylglyoxal; negative regulation of circadian rhythm; positive regulation of transcription from RNA polymerase II promoter; gene expression; hemopoietic progenitor cell differentiation; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; positive regulation of defense response to virus by host; negative regulation of transcription, DNA-dependent; blood coagulation; DNA replication; activation of innate immune response; negative regulation of apoptosis; aging |
| NCBI Summary: | The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96ST3 |
| NCBI GenInfo Identifier: | 37999759 |
| NCBI Gene ID: | 25942 |
| NCBI Accession: | Q96ST3.2 |
| UniProt Secondary Accession: | Q96ST3,Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1, B2RNS5 |
| UniProt Related Accession: | Q96ST3 |
| Molecular Weight: | 1273 |
| NCBI Full Name: | Paired amphipathic helix protein Sin3a |
| NCBI Synonym Full Names: | SIN3 transcription regulator family member A |
| NCBI Official Symbol: | SIN3AÂ Â |
| NCBI Protein Information: | paired amphipathic helix protein Sin3a; SIN3A; transcriptional regulator, SIN3A; transcriptional corepressor Sin3a; transcriptional co-repressor Sin3A; SIN3 transcription regulator homolog A; SIN3 homolog A, transcription regulator; histone deacetylase complex subunit Sin3a |
| UniProt Protein Name: | Paired amphipathic helix protein Sin3a |
| UniProt Synonym Protein Names: | Histone deacetylase complex subunit Sin3a; Transcriptional corepressor Sin3a |
| Protein Family: | Paired amphipathic helix protein |
| UniProt Gene Name: | SIN3AÂ Â |
| UniProt Entry Name: | SIN3A_HUMAN |
