Sod1 Antibody (PACO30068)
- SKU:
- PACO30068
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IP
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Sod1 Antibody (PACO30068) |
| Antibody SKU: | PACO30068 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IP |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:10-1:100, IP:1:200-1:2000 |
| Species Reactivity: | Mouse, Rat, Human |
| Immunogen: | Recombinant Mouse Superoxide dismutase [Cu-Zn] protein (2-154AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO30068 at dilution of 1:10. |
 | Western Blot Positive WB detected in: Hela whole cell lysate, 293T whole cell lysate, HepG2 whole cell lysate, Jurkat whole cell lysate, Rat brain tissue, Rat liver tissue, Mouse brain tissue All lanes: Sod1 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 16 kDa Observed band size: 16 kDa . |
 | Immunoprecipitating Sod1 in HEK293 whole cell lysate Lane 1: Rabbit control IgG instead of PACO30068 in HEK293 whole cell lysate.For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000) Lane 2: PACO30068 (8µg) + HEK293 whole cell lysate (500µg) Lane 3: HEK293 whole cell lysate (10µg) . |
| Background: | Destroys radicals which are normally produced within the cells and which are toxic to biological systems. |
| Synonyms: | Superoxide dismutase [Cu-Zn] (EC 1.15.1.1), Sod1 |
| UniProt Protein Function: | SOD1: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Homodimer; non-disulfide linked. Homodimerization may take place via the ditryptophan cross-link at Trp-33. The pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not. The pathogenic variants ALS1 Arg-86 and Ala-94 interact with MARCH5, whereas wild-type protein does not. Belongs to the Cu-Zn superoxide dismutase family. |
| UniProt Protein Details: | Protein type:EC 1.15.1.1; Apoptosis; Nuclear receptor co-regulator; Oxidoreductase; Mitochondrial Cellular Component: cell soma; cytoplasm; cytoplasmic vesicle; cytosol; dendrite cytoplasm; extracellular matrix; extracellular region; extracellular space; lysosome; mitochondrial intermembrane space; mitochondrion; myelin sheath; neuron projection; nucleoplasm; nucleus; peroxisome; plasma membrane; protein complex; secretory granule Molecular Function:antioxidant activity; chaperone binding; copper ion binding; enzyme binding; identical protein binding; metal ion binding; oxidoreductase activity; protein binding; protein phosphatase 2B binding; Rac GTPase binding; superoxide dismutase activity; zinc ion binding Biological Process: activation of MAPK activity; aging; anterograde axon cargo transport; auditory receptor cell stereocilium organization and biogenesis; cell aging; cellular iron ion homeostasis; embryo implantation; glutathione metabolic process; heart contraction; hydrogen peroxide biosynthetic process; locomotory behavior; muscle maintenance; myelin maintenance in the peripheral nervous system; myeloid cell homeostasis; negative regulation of apoptosis; negative regulation of cholesterol biosynthetic process; negative regulation of neuron apoptosis; neurofilament cytoskeleton organization and biogenesis; ovarian follicle development; positive regulation of catalytic activity; positive regulation of cytokine production; positive regulation of superoxide release; regulation of blood pressure; regulation of GTPase activity; regulation of mitochondrial membrane potential; regulation of multicellular organism growth; regulation of protein kinase activity; relaxation of vascular smooth muscle; removal of superoxide radicals; response to axon injury; response to copper ion; response to drug; response to ethanol; response to heat; response to hydrogen peroxide; response to nutrient levels; response to organic substance; response to oxidative stress; response to reactive oxygen species; response to superoxide; retinal homeostasis; retrograde axon cargo transport; sensory perception of sound; spermatogenesis; superoxide metabolic process; superoxide release; transmission of nerve impulse |
| UniProt Code: | P08228 |
| NCBI GenInfo Identifier: | 45597447 |
| NCBI Gene ID: | 20655 |
| NCBI Accession: | NP_035564.1 |
| UniProt Related Accession: | P08228 |
| Molecular Weight: | 17.8 kDa |
| NCBI Full Name: | superoxide dismutase |
| NCBI Synonym Full Names: | superoxide dismutase 1, soluble |
| NCBI Official Symbol: | Sod1Â Â |
| NCBI Official Synonym Symbols: | Ipo1; SODC; Ipo-1; Sod-1; CuZnSOD; Cu/Zn-SOD; B430204E11Rik  |
| NCBI Protein Information: | superoxide dismutase [Cu-Zn] |
| UniProt Protein Name: | Superoxide dismutase [Cu-Zn] |
| Protein Family: | Superoxide dismutase |
| UniProt Gene Name: | Sod1Â Â |
| UniProt Entry Name: | SODC_MOUSE |
| ELISA Kits |
| Mouse SOD1 / Superoxide dismutase 1 ELISA Kit |
| Mouse Superoxide dismutase [Cu-Zn] (Sod1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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